Processing and presentation of self-antigens and foreign antigens and their loading into class I and class II molecules of the major histocompatibility complex (MHC) constitute a major feature of the cellular immune response and induce CD8 and CD4 T cell immune responses (1, 2), respectively. The MHC complex, in human, called human leukocyte antigen complex (HLA), is the most polymorphic locus of the mammalian genome, with hundreds of allelic variations, with the most polymorphic domain represented by the peptide binding domain (3, 4). Different MHC alleles have different antigen-binding profiles which, in turn, can affect the susceptibility or resistance to infectious diseases (4). MHC alleles are believed to be maintained by pathogen-driven selection, mediated through either heterozygote advantage or frequency-dependent selection (5).

中文翻译：

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HLA多态性和胰蛋白酶的独立性影响HIV和登革热病毒感染的结果[免疫学和炎症]

处理和自身抗原和外源抗原和其装载到I类和II类主要组织相容性复合体（MHC）的分子的呈现构成所述细胞免疫反应的一个主要特征，诱导CD8和CD4 T细胞免疫应答（1，2）， 分别。该MHC复合物，在人类，称为人白细胞抗原复合物（HLA），是哺乳动物基因组的最多态性基因座，与数百等位基因变异的，具有最多态域中表示由肽结合结构域（3，4）。不同的MHC等位基因具有不同的抗原结合图谱，进而会影响对传染病的易感性或耐药性（4）。MHC等位基因被认为是由病原体驱动的选择维持的，通过杂合子优势或频率依赖性选择介导（5）。