Hydrogel‐Forming Microneedles: Current Advancements and Future Trends,Macromolecular Bioscience

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Hydrogel‐Forming Microneedles: Current Advancements and Future Trends
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-11-26 , DOI: 10.1002/mabi.202000307
Joseph G Turner _{1,

2} , Leah R White ₁ , Pedro Estrela _{2,

3} , Hannah S Leese _{1,

2}

Affiliation

In this focused progress review, the recent developments and trends of hydrogel‐forming microneedles (HFMs) and potential future directions are presented. Previously, microneedles (solid, hollow, coated, and dissolving microneedles) have primarily been used to enhance the effectiveness of transdermal drug delivery to facilitate a wide range of applications such as vaccinations and antibiotic delivery. However, the recent trend in microneedle development has resulted in microneedles formed from hydrogels which have the ability to offer transdermal drug delivery and, due to the hydrogel swelling nature, passively extract interstitial fluid from the skin, meaning they have the potential to be used for biocompatible minimally invasive monitoring devices. Thus, in this review, these recent trends are highlighted, which consolidate microneedle design considerations, hydrogel formulations, fabrication processes, applications of HFMs and the potential future opportunities for utilizing HFMs for personalized healthcare monitoring and treatment.

中文翻译：

水凝胶成型微针：当前进展和未来趋势

在这篇重点进展综述中，介绍了水凝胶成型微针 (HFM) 的最新发展和趋势以及潜在的未来方向。以前，微针（实心、空心、涂层和溶解微针）主要用于提高透皮给药的有效性，以促进广泛的应用，如疫苗接种和抗生素给药。然而，最近微针发展的趋势导致由水凝胶形成的微针能够提供透皮药物递送，并且由于水凝胶膨胀的性质，从皮肤中被动提取组织液，这意味着它们有可能用于生物相容性微创监测设备。因此，在本次审查中，强调了这些最近的趋势，

更新日期：2020-11-26

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