Polyhydroxyalkanoates (PHAs), also known as bacterial polyesters, are considered novel polymers for fabricating biomedical products, such as sutures and hernia meshes, because of their biocompatibility and slow biodegradability. Poly‐4‐hydroxybutyrate (P4HB) is a commonly used PHA that was explored in this study as an absorbable biomaterial for several medical applications, including controlled drug delivery. Currently, P4HB is melt spun and drawn into filaments at high processing temperatures (~200°C), precluding the incorporation of thermally sensitive drugs within the polymer during melt spinning. Post‐spinning drug incorporation can potentially cause nonuniform drug absorption that leads to an uneven release profile. This raises the need for a low temperature spinning process for these polymers. Until now, there has been no defined procedure to produce P4HB fibers through a low temperature solution spinning process. This study focuses on determining suitable wet spinning conditions to form continuous P4HB fibers. After several preliminary tests, it was found that a chloroform‐based spin dope with 10–15% polymer concentration facilitated the extrusion of continuous stretchable fibers into a coagulation bath containing reagent alcohol. Subsequently, several P4HB fibers were spun with various spin dope concentrations, coagulation bath temperatures, and spin draw ratios to assess their effect on fiber structure and properties.

中文翻译：

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湿纺条件对聚-4-羟基丁酸酯纤维结构和性能的影响

聚羟基链烷酸酯 (PHA)，也称为细菌聚酯，由于其生物相容性和缓慢的生物降解性，被认为是用于制造生物医学产品（如缝合线和疝网）的新型聚合物。聚-4-羟基丁酸酯 (P4HB) 是一种常用的 PHA，在本研究中被探索为可吸收的生物材料，可用于多种医疗应用，包括受控药物输送。目前，P4HB 是在高加工温度（~200°C）下熔融纺丝并拉制成长丝，从而在熔融纺丝过程中阻止了热敏药物在聚合物中的掺入。纺丝后药物掺入可能会导致药物吸收不均匀，从而导致释放曲线不均匀。这提高了对这些聚合物的低温纺丝工艺的需求。到目前为止，目前还没有通过低温溶液纺丝工艺生产 P4HB 纤维的明确程序。本研究的重点是确定合适的湿纺条件以形成连续的 P4HB 纤维。经过几次初步测试，发现聚合物浓度为 10-15% 的基于氯仿的纺丝原液有助于将连续可拉伸纤维挤出到含有试剂酒精的凝固浴中。随后，用不同的纺丝原液浓度、凝固浴温度和纺丝拉伸比纺制了几种 P4HB 纤维，以评估它们对纤维结构和性能的影响。发现聚合物浓度为 10-15% 的基于氯仿的纺丝原液有助于将连续可拉伸纤维挤出到含有试剂酒精的凝固浴中。随后，用不同的纺丝原液浓度、凝固浴温度和纺丝拉伸比纺制了几种 P4HB 纤维，以评估它们对纤维结构和性能的影响。发现聚合物浓度为 10-15% 的基于氯仿的纺丝原液有助于将连续可拉伸纤维挤出到含有试剂酒精的凝固浴中。随后，用不同的纺丝原液浓度、凝固浴温度和纺丝拉伸比纺制了几种 P4HB 纤维，以评估它们对纤维结构和性能的影响。