Brain dysconnectivity relates to disability and cognitive impairment in multiple sclerosis,Human Brain Mapping

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Brain dysconnectivity relates to disability and cognitive impairment in multiple sclerosis
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-11-26 , DOI: 10.1002/hbm.25247
Martin Sjøgård ₁ , Vincent Wens _{1,

2} , Jeroen Van Schependom _{3,

4} , Lars Costers ₃ , Marie D'hooghe _{3,

4} , Miguel D'haeseleer _{3,

4} , Mark Woolrich ₅ , Serge Goldman _{1,

2} , Guy Nagels _{3,

4,

6} , Xavier De Tiège _{1,

2}

Affiliation

The pathophysiology of cognitive dysfunction in multiple sclerosis (MS) is still unclear. This magnetoencephalography (MEG) study investigates the impact of MS on brain resting‐state functional connectivity (rsFC) and its relationship to disability and cognitive impairment. We investigated rsFC based on power envelope correlation within and between different frequency bands, in a large cohort of participants consisting of 99 MS patients and 47 healthy subjects. Correlations were investigated between rsFC and outcomes on disability, disease duration and 7 neuropsychological scores within each group, while stringently correcting for multiple comparisons and possible confounding factors. Specific dysconnections correlating with MS‐induced physical disability and disease duration were found within the sensorimotor and language networks, respectively. Global network‐level reductions in within‐ and cross‐network rsFC were observed in the default‐mode network. Healthy subjects and patients significantly differed in their scores on cognitive fatigue and verbal fluency. Healthy subjects and patients showed different correlation patterns between rsFC and cognitive fatigue or verbal fluency, both of which involved a shift in patients from the posterior default‐mode network to the language network. Introducing electrophysiological rsFC in a regression model of verbal fluency and cognitive fatigue in MS patients significantly increased the explained variance compared to a regression limited to structural MRI markers (relative thalamic volume and lesion load). This MEG study demonstrates that MS induces distinct changes in the resting‐state functional brain architecture that relate to disability, disease duration and specific cognitive functioning alterations. It highlights the potential value of electrophysiological intrinsic rsFC for monitoring the cognitive impairment in patients with MS.

中文翻译：

脑连接障碍与多发性硬化症的残疾和认知障碍有关

多发性硬化症 (MS) 认知功能障碍的病理生理学仍不清楚。这项脑磁图 (MEG) 研究调查了 MS 对大脑静息状态功能连接 (rsFC) 的影响及其与残疾和认知障碍的关系。我们在由 99 名 MS 患者和 47 名健康受试者组成的大型参与者队列中，基于不同频带内和之间的功率包络相关性研究了 rsFC。研究了 rsFC 与每组内残疾、疾病持续时间和 7 项神经心理学评分之间的相关性，同时严格校正多重比较和可能的混杂因素。在感觉运动和语言网络中分别发现了与 MS 引起的身体残疾和疾病持续时间相关的特定障碍。在默认模式网络中观察到网络内和跨网络 rsFC 的全球网络级减少。健康受试者和患者在认知疲劳和语言流利度方面的得分存在显着差异。健康受试者和患者在 rsFC 与认知疲劳或语言流畅性之间表现出不同的相关模式，这两者都涉及患者从后默认模式网络到语言网络的转变。与仅限于结构 MRI 标志物（相对丘脑体积和病变负荷）的回归相比，在 MS 患者语言流畅性和认知疲劳的回归模型中引入电生理学 rsFC 显着增加了解释方差。这项 MEG 研究表明，MS 会引起与残疾相关的静息状态大脑功能结构的明显变化，疾病持续时间和特定的认知功能改变。它强调了电生理内在 rsFC 在监测 MS 患者认知障碍方面的潜在价值。

更新日期：2021-01-19

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