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Long-term pharmacological torpor of rats with feedback-controlled drug administration
Life Sciences in Space Research ( IF 2.5 ) Pub Date : 2020-11-26 , DOI: 10.1016/j.lssr.2020.11.002
Nadezhda M Zakharova 1 , Yury S Tarahovsky 2 , Natalia P Komelina 1 , Irina S Fadeeva 2 , Anatoly L Kovtun 3
Affiliation  

The maintenance of pharmacological torpor and hypothermia (body temperature 28 °C - 33 °C) in rats for a week is presented. For this purpose, our laboratory has developed a device (BioFeedback-2) for the feed-back controlled multiple injections of small doses of a pharmacological composition that we created earlier. On the 7th day, the rat spontaneously come out of the pharmacological torpor, the body temperature returned to normal, and on the 8th day, the animal could consume food and water. The proposed approach for maintaining multi-day pharmacological torpor can be applied in medicine, as well as for protecting astronauts during long missions in space.



中文翻译:

反馈控制给药大鼠的长期药理麻木

提出了维持大鼠一周的药理麻木和体温过低(体温 28 °C - 33 °C)。为此,我们的实验室开发了一种设备 (BioFeedback-2),用于反馈控制多次注射我们之前创建的小剂量药理成分。第7天,大鼠自发摆脱药理麻木,体温恢复正常,第8天,可以进食和饮水。所提出的维持多日药理学麻木的方法可应用于医学,以及在太空长期任务中保护宇航员。

更新日期:2020-12-01
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