The present longitudinal study investigated the effects of early childhood socioeconomic status on language-related resting-state functional connectivity and reading outcome in adolescence. Seventy-nine children participated in this study. Socioeconomic status was measured via parent questionnaire measuring parental education and family income at 1 month. At age 14, resting-state fMRI data and reading-related behavioral data of the children were collected. Resting-state functional connectivity (RSFC) analysis was performed based on four regions of interest, including the left inferior frontal gyrus (L.IFG), left anterior superior temporal gyrus (L.aSTG), left posterior superior temporal gyrus (L.pSTG) and right anterior superior temporal gyrus (R.aSTG). Significant associations were found between parental education and the language-related RSFC, including the RSFC of L.IFG-L.aSTG and the RSFC of L.aSTG-L.pSTG, while no association was found between family income and language-related RSFC. Furthermore, the parental education-associated functional connectivity patterns (i.e., L.IFG-L.aSTG and L.aSTG-L.pSTG) were found to be positively correlated with children’s reading skills (word list reading and sentence reading fluency). Finally, path analyses indicated that the intrinsic brain connectivity between L.aSTG and L.pSTG influenced the relationship between parental education and children’s reading outcomes.

目前的纵向研究调查了儿童早期社会经济状况对与语言相关的休息状态功能连接和青春期阅读结局的影响。七十九名儿童参加了这项研究。通过父母问卷调查社会经济状况，该问卷测量了1个月时的父母教育和家庭收入。在14岁时，收集了儿童的静息状态fMRI数据和与阅读相关的行为数据。基于四个感兴趣的区域，包括左下额回（L.IFG），左前颞上回（L.aSTG），左后颞上回（L.pSTG）进行了静息状态功能连接（RSFC）分析。 ）和右前颞上回（R.aSTG）。在父母教育和与语言相关的RSFC之间发现了重要的关联，包括L.IFG-L.aSTG的RSFC和L.aSTG-L.pSTG的RSFC，而在家庭收入和与语言相关的RSFC之间未发现关联。此外，发现与父母教育相关的功能连接模式（即L.IFG-L.aSTG和L.aSTG-L.pSTG）与儿童的阅读技能（单词表阅读和句子阅读流畅度）呈正相关。最后，路径分析表明，L.aSTG和L.pSTG之间固有的大脑连通性影响了父母教育与儿童阅读结果之间的关系。pSTG）与儿童的阅读能力（单词表阅读和句子阅读流畅度）呈正相关。最后，路径分析表明，L.aSTG和L.pSTG之间固有的大脑连通性影响了父母教育与儿童阅读结果之间的关系。pSTG）与儿童的阅读能力（单词表阅读和句子阅读流畅度）呈正相关。最后，路径分析表明，L.aSTG和L.pSTG之间固有的大脑连通性影响了父母教育与儿童阅读结果之间的关系。