The effectiveness of outer hair cells (OHCs) in amplifying the motion of the organ of Corti, and thereby contributing to the sensitivity of mammalian hearing, depends on the mechanical power output of these cells. Electromechanical coupling in OHCs, which enables these cells to convert electrical energy into mechanical energy, has been analyzed in detail using isolated cells using primarily static membrane models. Mechanical output of the OHC was previously evaluated by developing a kinetic theory based on a simplified one-dimensional (1D) model for OHCs. Here, a kinetic description of OHCs is extended by using the membrane model, which was used for analyzing in vitro experiments. The present theory predicts, for systems without inertial load, that elastic load enhances positive shift of voltage dependence of the membrane capacitance due to turgor pressure. The effect of turgor pressure increases with increasing elastic load. For systems with inertia, the magnitude of mechanical power output could be ∼5 % higher than the value predicted by the 1D model at the optimal turgor pressure.

中文翻译：

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外毛细胞动力学膜模型

外毛细胞 (OHC) 在放大 Corti 器官运动并因此有助于哺乳动物听觉敏感性方面的有效性取决于这些细胞的机械功率输出。OHC 中的机电耦合使这些电池能够将电能转换为机械能，已经使用主要使用静态膜模型的隔离电池进行了详细分析。OHC 的机械输出先前是通过开发基于 OHC 的简化一维 (1D) 模型的动力学理论来评估的。在这里，通过使用膜模型扩展了 OHC 的动力学描述，该模型用于分析体外实验。本理论预测，对于没有惯性负载的系统，由于膨胀压力，弹性负载增强了膜电容的电压依赖性的正移。膨胀压力的影响随着弹性载荷的增加而增加。对于具有惯性的系统，机械功率输出的大小可能比一维模型在最佳膨胀压力下预测的值高 5%。