The increasing prevalence of bacterial pathogens with multiple antibiotic resistance requires development of new approaches to control infections. Phage therapy is one of the most promising approaches. In recent years, research organizations and a number of pharmaceutical companies have intensified investigations aimed at developing bacteriophage-based therapeutics. In the United States and European countries, special centers have been established that experimentally apply phage therapy to treat patients who do not respond to antibiotic therapy. This review describes the features of bacteriophages as therapeutic tools, critically discusses the results of clinical trials of bacteriophage preparations, and assesses the prospects for using phage therapy to treat certain types of infectious diseases.

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噬菌体作为治疗制剂：是什么限制了它们在医学中的应用

具有多种抗生素耐药性的细菌病原体日益流行，需要开发控制感染的新方法。噬菌体疗法是​​最有前途的方法之一。近年来，研究机构和一些制药公司加强了旨在开发基于噬菌体疗法的研究。在美国和欧洲国家，已经建立了专门的中心，实验性地应用噬菌体疗法来治疗对抗生素疗法没有反应的患者。这篇综述描述了噬菌体作为治疗工具的特点，批判性地讨论了噬菌体制剂的临床试验结果，并评估了使用噬菌体疗法治疗某些类型传染病的前景。