This review discusses main directions and results of the studies on antibiotics produced by bacteria living in the marine environment. In recent years many obligate marine species and strains were studied, diverse metabolites were isolated, and their chemical structures were elucidated. Among them here were natural compounds toxic against tumor cells, pathogenic bacteria, viruses, and malaria plasmodial species; these compounds often had no analogues among the natural products of terrestrial origin. Some isolated compounds form a basis of active ingredients in medicinal preparations used in clinic practice, while others are under different stages of preclinical or clinical studies. Much attention has been paid in recent years to producers of marine-derived antibiotics isolated from the deep-sea habitats, from the surface of marine invertebrates and algae, as well as from symbiotic microorganisms.

中文翻译：

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来自海洋细菌的抗生素

本综述讨论了海洋环境中细菌产生的抗生素研究的主要方向和结果。近年来，研究了许多专性海洋物种和菌株，分离了多种代谢物，并阐明了它们的化学结构。其中包括对肿瘤细胞、致病细菌、病毒和疟疾疟原虫物种有毒的天然化合物；这些化合物在来自陆地的天然产物中通常没有类似物。一些分离的化合物构成了临床实践中使用的药物制剂中活性成分的基础，而另一些则处于临床前或临床研究的不同阶段。近年来，人们对从深海栖息地中分离出来的海洋衍生抗生素的生产者给予了很多关注，