In this work, a sensor for quantitative detection of uric acid (UA) is successfully prepared by electrodepositing Nickel–Copper (Ni–Cu) alloy nanoparticles on poly (3,4-ethyldioxythiophene) modified nitrogen-containing grapheme (Ni–Cu/PEDOT/NGE). The anchoring of PEDOT and Cu–Ni alloy nanoparticles on NGE not only prevents the agglomeration of NGE, but also improves the catalytic activity of the composites. Ni–Cu/PEDOT/NGE shows high electrochemical performance to UA and the oxidation of UA on its interface was an action with two protons and two electrons. Under the optimized condition, the response current of the sensor is linear with UA concentration within the range of 0.1–10[Formula: see text][Formula: see text]M and 10–50[Formula: see text][Formula: see text]M. A low detection limit of 0.059[Formula: see text][Formula: see text]M at S/[Formula: see text] is obtained. Additionally, the fabricated electrochemical sensor with good sensitivity and selectivity to UA may be promising for practical clinical testing.

中文翻译：

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镍铜合金纳米复合材料的电化学合成制备尿酸电化学传感器

在这项工作中，通过在聚（3,4-乙基二氧噻吩）改性的含氮石墨烯（Ni-Cu/PEDOT）上电沉积镍-铜（Ni-Cu）合金纳米粒子，成功制备了一种用于尿酸（UA）定量检测的传感器。 /NGE)。PEDOT和Cu-Ni合金纳米粒子在NGE上的锚定不仅可以防止NGE的团聚，还可以提高复合材料的催化活性。Ni-Cu/PEDOT/NGE对UA表现出高电化学性能，UA在其界面上的氧化是两个质子和两个电子的作用。在优化条件下，传感器的响应电流与UA浓度在0.1-10[公式：见正文][公式：见正文]M和10-50[公式：见正文][公式：见正文]范围内呈线性关系文]M．低检测限 0.059[公式：见正文][公式：见文本]M 在 S/[公式：见文本] 处获得。此外，制备的电化学传感器对 UA 具有良好的灵敏度和选择性，可能有希望用于实际的临床测试。