Optimal synthesis of polyelectrolyte nanogels by electrostatic assembly directed polymerization for dye loading and release,Soft Matter

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Optimal synthesis of polyelectrolyte nanogels by electrostatic assembly directed polymerization for dye loading and release
Soft Matter ( IF 2.9 ) Pub Date : 2020-11-16 , DOI: 10.1039/d0sm01715a
Peng Ding _{1,

2,

3,

4} , Wei Liu _{1,

2,

3,

4} , Xuhong Guo _{1,

2,

3,

4} , Martien A. Cohen Stuart _{1,

2,

3,

4} , Junyou Wang _{1,

2,

3,

4}

Affiliation

Polyelectrolyte (PE) nanogels which combine features of nanogels and polyelectrolytes have attracted significant attention as outstanding nano-carriers. However, and crucially, any large-scale application of PE nanogels can only materialize when an efficient production method is available. We recently developed such a robust approach, namely Electrostatic Assembly Directed Polymerization (EADP), in which ionic monomers are polymerized together with cross-linker in the presence of a polyion-neutral diblock copolymer as template. Although EADP achieves efficient and scalable preparation of diverse PE nanogels, the essential factors for the optimal and controlled synthesis of nanogels have remained elusive. In this article, we investigate systematically the effects of pH, salt concentration, and cross-linker fractions on the formation and properties of a PDMAEMA nanogel prepared with PAA-b-PEO as the template. We find that the electrostatic interaction between the building blocks is crucial to obtain assembly-controlled polymerization, and we establish preferred pH, salt concentration and cross-linker fractions. The obtained PDMAEMA nanogel exhibits dual-responses to pH and salt, which allow manipulation of the positive charges of the nanogels for selective loading and controlled release of anionic substances; we demonstrate this with an anionic dye. The study presented here fully addresses the process parameters of EADP regarding optimal and controlled preparation of PE nanogels, which should allow exploration of their potential vis-a-vis a variety of applications.

中文翻译：

静电组装定向聚合用于染料加载和释放的聚电解质纳米凝胶的最佳合成

结合纳米凝胶和聚电解质特性的聚电解质（PE）纳米凝胶作为出色的纳米载体已引起了广泛的关注。然而，至关重要的是，只有在有有效的生产方法时，PE纳米凝胶的任何大规模应用才能实现。我们最近开发了一种可靠的方法，即静电组装定向聚合（EADP），其中离子单体在聚离子-中性二嵌段共聚物作为模板的情况下与交联剂一起聚合。尽管EADP可以高效，可扩展地制备各种PE纳米凝胶，但是优化和控制纳米凝胶合成的基本因素仍然难以捉摸。在本文中，我们系统地研究了pH，盐浓度，b -PEO作为模板。我们发现构件之间的静电相互作用对于获得组装控制的聚合至关重要，并且我们确定了优选的pH，盐浓度和交联剂级分。所获得的PDMAEMA纳米凝胶对pH和盐具有双重响应，从而可以操纵纳米凝胶的正电荷以选择性负载和控制释放阴离子物质。我们用阴离子染料证明了这一点。这项研究提出了在这里完全满足EADP关于优化和PE纳米凝胶的可控制备工艺参数，它应该允许其潜在的勘探面对面的人的各种应用。

更新日期：2020-11-25

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