N6-Methyladenosine (m6A) is the most abundant, dynamic, and reversible epigenetic RNA modification that is found in coding and non-coding RNAs. Emerging studies have shown that m6A and its regulators affect multiple steps in RNA metabolism and play broad roles in various cancers. Worldwide, breast cancer is the most prevalent cancer in female. It is a very heterogeneous disease characterized by genetic and epigenetic variations in tumor cells. Increasing evidence has shown that the dysregulation of m6A-related effectors, as methyltransferases, demethylases, and m6A binding proteins, is pivotal in breast cancer pathogenesis. In this review, we have summarized the most up-to-date research on the biological functions of m6A modification in breast cancer and have discussed the potential clinical applications and future directions of m6A modification as a biomarker as well as a therapeutic target of breast cancer.

中文翻译：

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N6-甲基腺苷 (m6A) 修饰在乳腺癌中的新作用

N6-甲基腺苷 (m6A) 是编码和非编码 RNA 中最丰富、动态且可逆的表观遗传 RNA 修饰。新兴研究表明 m6A 及其调节因子影响 RNA 代谢的多个步骤，并在各种癌症中发挥广泛作用。在世界范围内，乳腺癌是女性中最常见的癌症。这是一种非常异质的疾病，其特征是肿瘤细胞的遗传和表观遗传变异。越来越多的证据表明，m6A 相关效应子（如甲基转移酶、去甲基酶和 m6A 结合蛋白）的失调在乳腺癌发病机制中至关重要。在这篇综述中，我们总结了m6A修饰在乳腺癌中生物学功能的最新研究，并讨论了m6A修饰作为乳腺癌生物标志物和治疗靶点的潜在临床应用和未来方向。