Interleukin-1 receptor antagonist (IL1RN) has been reported as a biomarker of many cancers. However, the biological function of IL1RN in papillary thyroid carcinoma (PTC) remains undetermined. We obtained IL1RN expression data from The Cancer Genome Atlas (TCGA) database. Enrichment analysis of coexpressed genes and IL1RN methylation analysis were performed via LinkedOmics. The correlations between IL1RN and immune infiltrates were investigated via ESTIMATE, TIMER and TISIDB. We analyzed the association of IL1RN expression with pancancer overall survival (OS) via Gene Expression Profiling Interactive Analysis (GEPIA). IL1RN showed higher expression levels and lower methylation levels in PTC tissues than in normal tissues. Higher IL1RN expression was significantly associated with shorter progression-free survival (PFS), advanced tumor stage, tumor metastasis, increased incidence of BRAF mutations, and decreased incidence of N-RAS and H-RAS mutations. Genes coexpressed with IL1RN participate primarily in immune-related pathways. IL1RN expression positively correlated with immune infiltration, tumor progression and poor OS for all cancers. IL1RN is a good prognostic and diagnostic biomarker for PTC. IL1RN may promote thyroid cancer progression through immune-related pathways. Methylation may act as an upstream regulator of IL1RN expression and biological function. Additionally, IL1RN was shown to have broad prognostic value in a pancancer cohort.

中文翻译：

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白细胞介素1受体拮抗剂（IL1RN）在甲状腺乳头状癌中的表达及潜在分子机制的生物信息学分析

白介素-1受体拮抗剂（IL1RN）已被报道为许多癌症的生物标志物。但是，IL1RN在甲状腺乳头状癌（PTC）中的生物学功能仍未确定。我们从癌症基因组图谱（TCGA）数据库获得了IL1RN表达数据。共表达基因的富集分析和IL1RN甲基化分析通过LinkedOmics进行。通过ESTIMATE，TIMER和TISIDB研究了IL1RN与免疫浸润之间的相关性。我们通过基因表达谱交互分析（GEPIA）分析了IL1RN表达与胰腺癌总体生存率（OS）的关联。IL1RN在PTC组织中显示出比正常组织中更高的表达水平和更低的甲基化水平。IL1RN的较高表达与较短的无进展生存期（PFS），晚期肿瘤分期，肿瘤转移，BRAF突变发生率增加以及N-RAS和H-RAS突变发生率降低。与IL1RN共表达的基因主要参与免疫相关途径。IL1RN表达与所有癌症的免疫浸润，肿瘤进展和不良OS正相关。IL1RN是PTC的良好预后和诊断生物标志物。IL1RN可能通过免疫相关途径促进甲状腺癌的进展。甲基化可以充当IL1RN表达和生物学功能的上游调节剂。此外，IL1RN在胰腺癌队列中显示出广泛的预后价值。IL1RN表达与所有癌症的免疫浸润，肿瘤进展和不良OS正相关。IL1RN是PTC的良好预后和诊断生物标志物。IL1RN可能通过免疫相关途径促进甲状腺癌的进展。甲基化可以充当IL1RN表达和生物学功能的上游调节剂。此外，IL1RN在胰腺癌队列中显示出广泛的预后价值。IL1RN表达与所有癌症的免疫浸润，肿瘤进展和不良OS正相关。IL1RN是PTC的良好预后和诊断生物标志物。IL1RN可能通过免疫相关途径促进甲状腺癌的进展。甲基化可以充当IL1RN表达和生物学功能的上游调节剂。此外，IL1RN在胰腺癌队列中显示出广泛的预后价值。