Chamaejasmone F, a new 11,10-guaiane-type sesquiterpenoid, is isolated from the roots of Stellera chamaejasme Linn., along with four known compounds including two guaiane sesquiterpenoids and two lignans. The structure of the new compound is elucidated by extensive spectroscopic analysis, especially two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization mass spectrometry. The known compounds 1β-hydroxy-10βH-guaia-4,11-dien-3-one and (+)-hinokinin are isolated from the genus Stellera for the first time. In an in vitro assay, chamaejasmone F shows moderate cytotoxic activity against the human triple negative breast cancer cell line MB-MDA-231.

从Stellera chamaejasme Linn。的根中分离出一种新的11,10-guaiane型倍半萜类化合物Chamaejasmone F，以及四个已知化合物，其中包括两个guaiane倍半萜类化合物和两个木脂素。通过广泛的光谱分析，尤其是二维核磁共振光谱和高分辨率电喷雾电离质谱，阐明了该新化合物的结构。已知的化合物1β-羟基-10βH-guaia-4,11-dien-3-one和（+）-hinokinin首次从Stellera属中分离出来。在体外测定中，Chamaejasmone F对人三阴性乳腺癌细胞MB-MDA-231具有中等程度的细胞毒活性。