Chemical Protein Synthesis in Medicinal Chemistry,Journal of Medicinal Chemistry

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Chemical Protein Synthesis in Medicinal Chemistry
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2020-11-25 , DOI: 10.1021/acs.jmedchem.0c01082
Vangelis Agouridas _{1,

2} , Ouafâa El Mahdi ₃ , Oleg Melnyk ₁

Affiliation

Although the majority of proteins used for biomedical research are produced using living systems such as bacteria, biological means for producing proteins can be advantageously complemented by protein semisynthesis or total chemical synthesis. The latter approach is particularly useful when the proteins to be produced are toxic for the expression system or show unusual features that cannot be easily programmed in living organisms. The aim of this review is to provide a wide overview of the use of chemical protein synthesis in medicinal chemistry with a special focus on the production of post-translationally modified proteins and backbone cyclized proteins.

中文翻译：

药物化学中的化学蛋白质合成

尽管用于生物医学研究的大多数蛋白质是使用细菌等活体系统生产的，但用于蛋白质生产的生物学手段可以通过蛋白质半合成或全化学合成来有利地加以补充。当要生产的蛋白质对表达系统有毒性或显示出在活生物体中不容易编程的异常特征时，后一种方法特别有用。这篇综述的目的是提供化学蛋白质合成在药物化学中的广泛用途，特别着重于翻译后修饰的蛋白质和骨架环化蛋白质的生产。

更新日期：2020-12-24

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