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Microfluidic Tracking of the Growth of Polymeric Vesicles in Hydrodynamic Flow
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2020-11-25 , DOI: 10.1021/acsapm.0c01089 Xuan Don Nguyen 1 , Dong Hyeok Park 1 , Hyun-jong Paik 2 , Hyeong Jin Jeon 3 , June Huh 4 , Jeung Sang Go 1
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2020-11-25 , DOI: 10.1021/acsapm.0c01089 Xuan Don Nguyen 1 , Dong Hyeok Park 1 , Hyun-jong Paik 2 , Hyeong Jin Jeon 3 , June Huh 4 , Jeung Sang Go 1
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Polymeric vesicles (PVs) have proven to be a promising container for various agents because of the benefit of core–shell structures. The formation mechanism of PVs has been investigated in the hydrostatic media numerically and experimentally. However, it has been hardly reported in the hydrodynamic media of the microfluidic channel. This paper provides the visual evidence of the hydrodynamic formation mechanism of polystyrene-block-poly(ethylene glycol) vesicles. The PVs were prepared in a multiple lamination flow formed with a double flow-focusing microchannel (DFFM). To visualize the formation mechanism, the PV synthesis at each stage was characterized by scanning electron microscopy (SEM) taken along the microchannel length. Time-evolution of PV structure reveals that the formation of the PVs undergoes three distinctive morphological intermediates (micelles, disklike micelles, and semivesicles) before eventually reaching PVs, which can be tracked not only along the flow direction but also in its transverse direction. This mechanistic study for PV formation via microfluidic self-assembly provides an essential guideline for fabricating PVs with programmable morphologies that can be used in a variety of applications.
中文翻译：
流体流动中聚合物囊泡生长的微流控跟踪。
由于核壳结构的优势，聚合物囊泡（PVs）已被证明是用于各种药物的有前途的容器。在静水介质中对PVs的形成机理进行了数值和实验研究。然而，在微流体通道的流体动力学介质中几乎没有报道。本文为聚苯乙烯嵌段的水动力形成机理提供了直观的证据。-聚（乙二醇）囊泡。PVs是用双流聚焦微通道（DFFM）形成的多层流制备的。为了可视化形成机理，在每个阶段的PV合成都通过沿微通道长度的扫描电子显微镜（SEM）进行表征。PV结构的时间演变揭示了PV的形成在最终到达PV之前经历了三种独特的形态学中间产物（胶束，盘状微团和半囊泡），不仅可以沿流动方向而且可以沿其横向方向进行跟踪。通过微流体自组装形成PV的这一机理研究为制造具有可编程形态的PV提供了基本指导，可用于多种应用。
更新日期：2020-12-11
中文翻译：
流体流动中聚合物囊泡生长的微流控跟踪。
由于核壳结构的优势，聚合物囊泡（PVs）已被证明是用于各种药物的有前途的容器。在静水介质中对PVs的形成机理进行了数值和实验研究。然而，在微流体通道的流体动力学介质中几乎没有报道。本文为聚苯乙烯嵌段的水动力形成机理提供了直观的证据。-聚（乙二醇）囊泡。PVs是用双流聚焦微通道（DFFM）形成的多层流制备的。为了可视化形成机理，在每个阶段的PV合成都通过沿微通道长度的扫描电子显微镜（SEM）进行表征。PV结构的时间演变揭示了PV的形成在最终到达PV之前经历了三种独特的形态学中间产物（胶束，盘状微团和半囊泡），不仅可以沿流动方向而且可以沿其横向方向进行跟踪。通过微流体自组装形成PV的这一机理研究为制造具有可编程形态的PV提供了基本指导，可用于多种应用。
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