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Antimicrobial Activities of Zn-Doped CuO Microparticles Decorated on Polydopamine against Sensitive and Antibiotic-Resistant Bacteria
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2020-11-25 , DOI: 10.1021/acsapm.0c01104 Moorthy Maruthapandi , Arumugam Saravanan , Poushali Das , Michal Natan , Gila Jacobi , Ehud Banin , John H. T. Luong 1 , Aharon Gedanken
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2020-11-25 , DOI: 10.1021/acsapm.0c01104 Moorthy Maruthapandi , Arumugam Saravanan , Poushali Das , Michal Natan , Gila Jacobi , Ehud Banin , John H. T. Luong 1 , Aharon Gedanken
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A polydopamine (PDA) composite was synthesized by depositing Zn-doped CuO (Zn@CuO) particles on polydopamine by one-step ultrasonication. XPS, XRD, and FTIR confirmed the formation of spherical Zn@CuO on PDA with resulting diameters ranging from 1 to 5 μm. The PDA-Zn@CuO at 0.125–0.5 mg/mL exhibited a superior activity over Zn@CuO against sensitive and antibiotic-resistant bacteria. The Zn@CuO nanosized hybrid particles could penetrate the cell but interacted less effectively with bacterial biomolecules to provoke rapid cell lysis. PDA above 0.5 mg/mL also had a modest effect against Escherichia coli and Staphylococcus aureus. However, much higher PDA concentrations were required to restrict the flow of essential nutrients and wastes in and out of the cytoplasmic matrix and resulted in eventual cell death. The binding of PDA-Zn@CuO to bacteria played an important role in causing bacterial death, whereas reactive oxygen species (ROS) also effectively contributed to cell killing.
中文翻译：
聚多巴胺修饰的锌掺杂CuO微粒对敏感和抗细菌细菌的抗菌活性。
通过一步法超声将Zn掺杂的CuO（Zn @ CuO）颗粒沉积在聚多巴胺上来合成聚多巴胺（PDA）复合材料。XPS，XRD和FTIR证实了PDA上球形Zn @ CuO的形成，其直径范围为1至5μm。PDA-Zn @ CuO的浓度为0.125-0.5 mg / mL，对敏感和抗药性细菌的活性优于Zn @ CuO。Zn @ CuO纳米杂化颗粒可以穿透细胞，但与细菌生物分子的相互作用较弱，从而引起细胞快速裂解。PDA高于0.5 mg / mL对大肠杆菌和金黄色葡萄球菌也有中等作用。但是，需要更高的PDA浓度以限制必需营养素和废物流入和流出细胞质基质，并最终导致细胞死亡。PDA-Zn @ CuO与细菌的结合在导致细菌死亡中起着重要作用，而活性氧（ROS）也有效地导致了细胞杀伤。
更新日期：2020-11-25
中文翻译：
聚多巴胺修饰的锌掺杂CuO微粒对敏感和抗细菌细菌的抗菌活性。
通过一步法超声将Zn掺杂的CuO（Zn @ CuO）颗粒沉积在聚多巴胺上来合成聚多巴胺（PDA）复合材料。XPS，XRD和FTIR证实了PDA上球形Zn @ CuO的形成，其直径范围为1至5μm。PDA-Zn @ CuO的浓度为0.125-0.5 mg / mL，对敏感和抗药性细菌的活性优于Zn @ CuO。Zn @ CuO纳米杂化颗粒可以穿透细胞，但与细菌生物分子的相互作用较弱，从而引起细胞快速裂解。PDA高于0.5 mg / mL对大肠杆菌和金黄色葡萄球菌也有中等作用。但是，需要更高的PDA浓度以限制必需营养素和废物流入和流出细胞质基质，并最终导致细胞死亡。PDA-Zn @ CuO与细菌的结合在导致细菌死亡中起着重要作用，而活性氧（ROS）也有效地导致了细胞杀伤。
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