Dexmedetomidine is a novel, highly selective α2 adrenoceptor agonist, whereas oxycodone serves as a μ- and ĸ-amboceptor agonist. To analyze the effects of dexmedetomidine combined with oxycodone in locally anesthetized patients undergoing transforaminal endoscopic resection of nucleus pulposus. 112 patients were evenly randomized into oxycodone group (OG), dexmedetomidine group (DG), oxycodone-dexmedetomidine combination group (ODG), and control group (CG). No significant difference among the four groups in terms of baseline information, recovery time, or atropine was found (p > 0.05). The mean arterial pressures (MAPs) and heart rates (HRs) in ODG reduced from the injection point and were dramatically lower over those in CG, and visual analog scale (VAS) scores in ODG at 1, 2, and 6 h following surgery were lower over those in other groups (p < 0.05). The combination of dexmedetomidine with oxycodone in the local anesthesia during analgesia and sedation of patients undergoing transforaminal endoscopic resection of the nucleus pulposus manifested tangible effects. Specifically, such improved perioperative inflammatory responses and controlled cellular immunity without promoting the onset of adverse reactions.

右美托咪定是一种新型的，高度选择性的α2肾上腺素受体激动剂，而羟考酮则充当μ和γ受体激动剂。目的分析右美托咪定联合羟考酮在经椎间孔镜下髓核切除术中局部麻醉的患者中的作用。将112例患者随机分为羟考酮组（OG），右美托咪定组（DG），羟考酮-右美托咪定联合组（ODG）和对照组（CG）。在基线信息，恢复时间或阿托品方面，四组之间无显着差异（p > 0.05）。ODG的平均动脉压（MAPs）和心率（HRs）从注射点开始降低，并且比CG显着降低，并且在术后1、2和6 h ODG的视觉模拟量表（VAS）得分分别为低于其他组（p  <0.05）。在经椎间孔内镜下切除髓核的患者的镇痛和镇静过程中，右美托咪定与羟考酮的组合表现出明显的效果。特别地，这种改善的围手术期炎症反应和受控的细胞免疫而不促进不良反应的发作。