Restless in the mouse cage—A new genetic model for restless legs syndrome

J. Stegmüller

Restless legs syndrome (RLS) is a movement disorder that is characterized by an uncomfortable sensation in the legs, and the urge to move the legs. Meis1 has previously been identified as a risk gene for RLS. This Editorial highlights the study by Lyu and colleagues who developed a novel genetic mouse model heterozygous for Meis1 expression in neurons of the central nervous system. Using behavioral tests, the authors established hyperactivity of the mice, reminiscent of symptoms found in RLS patients. In addition, the authors took a closer look at the iron, dopaminergic, and cholinergic systems of these mice.

Read the highlighted article on page 522 and the full Editorial Highlight on page 471.

中文翻译：

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发行信息

老鼠笼中的躁动不安-腿不安定综合征的新遗传模型

斯泰格穆勒

腿不安综合症（RLS）是一种运动障碍，其特征是腿部感觉不适，并有移动腿部的冲动。Meis1先前已被确定为RLS的风险基因。这篇社论强调了Lyu及其同事的研究，他们为中枢神经系统神经元Meis1表达开发了一种杂合的新型遗传小鼠模型。使用行为测试，作者确定了小鼠活动亢进，使人联想到在RLS患者中发现的症状。此外，作者还仔细研究了这些小鼠的铁，多巴胺能和胆碱能系统。

阅读第522页上的突出显示的文章和第471页上的完整社论集锦。