Cold atmospheric plasma jet array for transdermal drug delivery,Plasma Processes and Polymers

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Cold atmospheric plasma jet array for transdermal drug delivery
Plasma Processes and Polymers ( IF 2.9 ) Pub Date : 2020-11-25 , DOI: 10.1002/ppap.202000180
Yang Lv ₁ , Lanlan Nie ₁ , Jiangwei Duan ₂ , Zhiyu Li ₁ , Xinpei Lu ₁

Affiliation

Transdermal drug delivery (TDD) is an important drug delivery method, and cold atmospheric plasma has been proven its potential as a TDD approach. In this study, a 9‐channel plasma jet array was designed to enhance TDD efficiency. The Franz diffusion experiment showed that the TDD efficiency of the drug across the skin was enhanced about 2–110 times after the plasma jet array treatment. The histological analysis showed that the structure of the stratum corneum could be destroyed by the plasma. Further investigations indicated that the reactive oxygen species of the plasma jet play a key role in enhancing TDD efficiency. Our results indicated that the plasma jet array is a potential and effective TDD approach.

中文翻译：

冷常压等离子体射流阵列，用于透皮给药

透皮药物递送（TDD）是一种重要的药物递送方法，而冷空气等离子体已被证明具有作为TDD方法的潜力。在本研究中，设计了9通道等离子流阵列以提高TDD效率。Franz扩散实验表明，等离子流阵列处理后，药物在皮肤上的TDD效率提高了约2–110倍。组织学分析表明，血浆可破坏角质层的结构。进一步的研究表明，等离子流的活性氧在提高TDD效率方面起着关键作用。我们的结果表明，等离子流阵列是一种潜在且有效的TDD方法。

更新日期：2020-11-25

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