Fragments recombination, design, synthesis, safener activity and CoMFA model of novel substituted dichloroacetylphenyl sulfonamide derivatives,Pest Management Science

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Fragments recombination, design, synthesis, safener activity and CoMFA model of novel substituted dichloroacetylphenyl sulfonamide derivatives
Pest Management Science ( IF 3.8 ) Pub Date : 2020-11-25 , DOI: 10.1002/ps.6193
Zi‐Wei Wang ₁ , Li‐Xia Zhao ₁ , Peng Ma ₁ , Tong Ye ₁ , Ying Fu ₁ , Fei Ye ₁

Affiliation

Isoxaflutole (IXF), as a kind of 4‐hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor, has been widely used in many kinds of plants. IXF can cause injury in corn including leaf and stem bleaching, plant height reduction or stunting, and reduced crop stand. Safeners are co‐applied with herbicides to protect crops without compromising weed control efficacy. With the ultimate goal of addressing Zea mays injury caused by IXF, a series of novel substituted dichloroacetylphenyl sulfonamide derivatives was designed on the basis of scaffold hopping and active substructure splicing.

中文翻译：

新型取代的二氯乙酰苯基磺酰胺衍生物的片段重组，设计，合成，安全活性和CoMFA模型

异氟草醚（IXF）是一种4-羟基苯基丙酮酸双加氧酶（HPPD）抑制剂，已广泛用于多种植物中。IXF可能对玉米造成伤害，包括叶片和茎的漂白，植物高度的降低或发育迟缓以及农作物减产。安全剂与除草剂共同使用可在不损害杂草防治功效的情况下保护农作物。为了解决IXF引起的Zea mays损伤的最终目标，在脚手架跳跃和活性亚结构剪接的基础上，设计了一系列新颖的取代的二氯乙酰苯基磺酰胺衍生物。

更新日期：2020-11-25

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