A solution solution: Synthetic AHL analogues (SAHLAs) have demonstrated efficacy as quorum sensing inhibitors by receptor antagonism. However, like native AHLs, these compounds are poorly soluble. To improve their solubility, we investigated the association of three representative SAHLAs, and their hydrolysis products, with β‐cyclodextrin by spectrofluorimetry and evaluated co‐application of CDs with SAHLAs in a C. elegans infection model.Drug delivery implications and quorum‐quenching exploits of beta‐cyclodextrin encapsulation of synthetic AHLs (Palmer @FloridaTech)

中文翻译：

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合成 AHL 的 β-环糊精包封：药物输送意义和群体淬灭漏洞

解决方案：合成 AHL 类似物 (SAHLA) 已通过受体拮抗作用证明作为群体感应抑制剂的功效。然而，与天然 AHL 一样，这些化合物的溶解性较差。为了提高它们的溶解度，我们通过荧光光谱法研究了三种代表性 SAHLA 及其水解产物与 β-环糊精的关联，并评估了 CD 与 SAHLA 在秀丽隐杆线虫感染模型中的共同应用。合成 AHL 的 β-环糊精封装（Palmer @FloridaTech）