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Biomimetic Anti‐PD‐1 Peptide‐Loaded 2D FePSe3 Nanosheets for Efficient Photothermal and Enhanced Immune Therapy with Multimodal MR/PA/Thermal Imaging
Advanced Science ( IF 14.3 ) Pub Date : 2020-11-25 , DOI: 10.1002/advs.202003041 Xueyang Fang 1 , Xianlin Wu 2, 3 , Zhendong Li 4 , Lijun Jiang 1 , Wai-Sum Lo 1 , Guanmao Chen 5 , Yanjuan Gu 1 , Wing-Tak Wong 1
Advanced Science ( IF 14.3 ) Pub Date : 2020-11-25 , DOI: 10.1002/advs.202003041 Xueyang Fang 1 , Xianlin Wu 2, 3 , Zhendong Li 4 , Lijun Jiang 1 , Wai-Sum Lo 1 , Guanmao Chen 5 , Yanjuan Gu 1 , Wing-Tak Wong 1
Affiliation
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Metal phosphorous trichalcogenides (MPX3) are novel 2D nanomaterials that have recently been exploited as efficient photothermal–chemodynamic agents for cancer therapy. As a representative MPX3, FePSe3 has the potential to be developed as magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) agents due to the composition of Fe and the previously revealed PA signal. Here, a FePSe3‐based theranostic agent, FePSe3@APP@CCM, loaded with anti‐PD‐1 peptide (APP) as the inner component and CT26 cancer cell membrane (CCM) as the outer shell is reported, which acts as a multifunctional agent for MR and PA imaging and photothermal and immunotherapy against cancer. FePSe3@APP@CCM induces highly efficient tumor ablation and suppresses tumor growth by photothermal therapy under near‐infrared laser excitation, which further activates immune responses. Moreover, APP blocks the PD‐1/PD‐L1 pathway to activate cytotoxic T cells, causing strong anticancer immunity. The combined therapy significantly prolongs the lifespan of experimental mice. The multimodal imaging and synergistic therapeutic effects of PTT and its triggered immune responses and APP‐related immunotherapy are clearly demonstrated by in vitro and in vivo experiments. This work demonstrates the potential of MPX3‐based biomaterials as novel theranostic agents.
中文翻译：
仿生抗 PD-1 肽负载 2D FePSe3 纳米片通过多模态 MR/PA/热成像实现高效光热和增强免疫治疗
金属磷三硫属化物（MPX 3）是新型二维纳米材料，最近被用作癌症治疗的有效光热化学动力学制剂。作为代表性MPX 3，FePSe 3由于Fe的成分和先前揭示的PA信号而具有开发作为磁共振成像（MRI）和光声成像（PAI）试剂的潜力。在此，报道了一种基于 FePSe 3的治疗诊断剂 FePSe 3 @APP@CCM，其负载抗 PD-1 肽（APP）作为内部成分，CT26 癌细胞膜（CCM）作为外壳，其作用是一种用于 MR 和 PA 成像以及光热和癌症免疫治疗的多功能制剂。FePSe 3 @APP@CCM 通过近红外激光激发下的光热疗法诱导高效肿瘤消融并抑制肿瘤生长，从而进一步激活免疫反应。此外，APP阻断PD-1/PD-L1通路激活细胞毒性T细胞，产生强大的抗癌免疫力。联合疗法显着延长了实验小鼠的寿命。PTT 及其引发的免疫反应和 APP 相关免疫治疗的多模态成像和协同治疗效果已通过体外和体内实验得到清楚的证明。这项工作证明了基于 MPX 3的生物材料作为新型治疗诊断剂的潜力。
更新日期：2021-01-20
中文翻译：
仿生抗 PD-1 肽负载 2D FePSe3 纳米片通过多模态 MR/PA/热成像实现高效光热和增强免疫治疗
金属磷三硫属化物（MPX 3）是新型二维纳米材料，最近被用作癌症治疗的有效光热化学动力学制剂。作为代表性MPX 3，FePSe 3由于Fe的成分和先前揭示的PA信号而具有开发作为磁共振成像（MRI）和光声成像（PAI）试剂的潜力。在此，报道了一种基于 FePSe 3的治疗诊断剂 FePSe 3 @APP@CCM，其负载抗 PD-1 肽（APP）作为内部成分，CT26 癌细胞膜（CCM）作为外壳，其作用是一种用于 MR 和 PA 成像以及光热和癌症免疫治疗的多功能制剂。FePSe 3 @APP@CCM 通过近红外激光激发下的光热疗法诱导高效肿瘤消融并抑制肿瘤生长，从而进一步激活免疫反应。此外，APP阻断PD-1/PD-L1通路激活细胞毒性T细胞，产生强大的抗癌免疫力。联合疗法显着延长了实验小鼠的寿命。PTT 及其引发的免疫反应和 APP 相关免疫治疗的多模态成像和协同治疗效果已通过体外和体内实验得到清楚的证明。这项工作证明了基于 MPX 3的生物材料作为新型治疗诊断剂的潜力。
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