Currently, the limited intratumoral H₂O₂ level restricts the development of chemodynamic therapy (CDT). Herein, MoSe₂/CoSe₂@PEG nanosheets are prepared to reveal NIR‐photocatalytic H₂O₂ generation to insure the intracellular H₂O₂ supplement. The formation mechanism is investigated, showing the dissolved O₂ and photo‐excited electrons to determine H₂O₂ production via sequential single‐electron transfer process. The experimental data and density functional theory calculation further display their typical‐II heterostructure, which possesses the effective charge separation and nearly four times H₂O₂ generation than MoSe₂@PEG. In addition, the nanocomposites also reveal the peroxidase/catalase activity, making the in‐situ H₂O₂ activation and ·OH generation. And, the O₂ production derived from catalase‐mimic activity not only relieves hypoxia but also offers the source for H₂O₂ production. Because of the decreased resistance for charge transfer, MoSe₂/CoSe₂@PEGs also reveal more than three times enzyme‐activity for MoSe₂@PEG. With the narrow band gap and high NIR‐harvest, MoSe₂/CoSe₂@PEG exhibits the great photothermal converting ability (62.5%). MoSe₂/CoSe₂@PEG reveals the novel biodegradation, and most of them can be eliminated via urine and feces within 2 weeks. Here, the computed tomography/magnetic resonance imaging/photothermal imaging and the synergistic photothermal therapy/CDT treatments further make sure potential application on anticancer.

中文翻译：

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通过协同原位H2O2产生和活化合成用于NIR增强化学动力学治疗的MoSe2 / CoSe2纳米片。

目前，有限的肿瘤内H ₂ O ₂水平限制了化学动力疗法（CDT）的发展。在这里，制备MoSe ₂ / CoSe ₂ @PEG纳米片以揭示NIR-光催化H ₂ O _2的产生，以确保细胞内H ₂ O _2的补充。研究了形成机理，显示了溶解的O ₂和光激发电子来确定H ₂ O ₂通过顺序单电子转移过程进行生产。实验数据和密度泛函理论计算进一步显示了它们典型的II型异质结构，该结构具有有效的电荷分离能力，是MoSe ₂ @PEG的H ₂ O ₂生成量的近四倍。此外，纳米复合材料还显示出过氧化物酶/过氧化氢酶活性，使原位H ₂ O ₂活化并生成·OH。而且，源自过氧化氢酶模拟活性的O ₂产生不仅减轻了缺氧，而且还提供了H ₂ O ₂产生的来源。由于电荷转移的阻力降低，因此MoSe ₂ / CoSe₂ @PEG还显示出MoSe ₂ @PEG的三倍以上的酶活性。MoSe ₂ / CoSe ₂ @PEG具有窄的带隙和高的近红外收率，表现出了很高的光热转换能力（62.5％）。MoSe ₂ / CoSe ₂ @PEG揭示了这种新型的生物降解作用，其中大多数可在2周内通过尿液和粪便消除。在此，计算机断层摄影/磁共振成像/光热成像以及协同光热疗法/ CDT治疗进一步确保了在抗癌方面的潜在应用。