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Tissue Engineering: Controlled Apoptosis of Stromal Cells to Engineer Human Microlivers (Adv. Funct. Mater. 48/2020)
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-11-25 , DOI: 10.1002/adfm.202070317
Amanda X. Chen 1, 2 , Arnav Chhabra 2, 3 , Hyun‐Ho Greco Song 3, 4, 5 , Heather E. Fleming 2, 3 , Christopher S. Chen 4, 5 , Sangeeta N. Bhatia 2, 3, 5, 6, 7
Affiliation  

Tools are limited in resolving the dynamic contributions of multicellular interactions in bioengineered tissues. In article number 1910442, Sangeeta N. Bhatia and co‐workers present CAMEO (controlled apoptosis in multicellular tissues for engineering organogenesis) as a strategy to precisely manipulate and study tissue composition. Herein, organoids comprised of hepatocytes (red) and fibroblasts (green) are used to glean new insights into 3D tissue biology.
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中文翻译:

组织工程:基质细胞的受控凋亡以工程化人类微肝(Adv。Funct。Mater。48/2020)

解决生物工程组织中多细胞相互作用的动态作用的工具受到限制。在第1910442号文章中,Sangeeta N. Bhatia和他的同事们提出了CAMEO(可控制多细胞组织中的细胞凋亡以进行工程器官发生)作为精确操纵和研究组织组成的策略。在本文中,由肝细胞(红色)和成纤维细胞(绿色)组成的类器官被用于收集有关3D组织生物学的新见解。
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更新日期:2020-11-25
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