Department of Biological Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA
Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA 02139 USA
Harvard–MIT Program in Health Sciences and Technology Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge MA 02139 USA
Biological Design Center Department of Biomedical Engineering Boston University Boston MA 02215 USA
Wyss Institute for Biologically Inspired Engineering Boston MA 02115 USA
Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA 02142 USA
Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA 02115 USA
Tools are limited in resolving the dynamic contributions of multicellular interactions in bioengineered tissues. In article number 1910442, Sangeeta N. Bhatia and co‐workers present CAMEO (controlled apoptosis in multicellular tissues for engineering organogenesis) as a strategy to precisely manipulate and study tissue composition. Herein, organoids comprised of hepatocytes (red) and fibroblasts (green) are used to glean new insights into 3D tissue biology.
解决生物工程组织中多细胞相互作用的动态作用的工具受到限制。在第1910442号文章中，Sangeeta N. Bhatia和他的同事们提出了CAMEO（可控制多细胞组织中的细胞凋亡以进行工程器官发生）作为精确操纵和研究组织组成的策略。在本文中，由肝细胞（红色）和成纤维细胞（绿色）组成的类器官被用于收集有关3D组织生物学的新见解。
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