Extracellular Matrix Remodelling: Obesity‐Associated Adipose Stromal Cells Promote Breast Cancer Invasion through Direct Cell Contact and ECM Remodeling (Adv. Funct. Mater. 48/2020),Advanced Functional Materials

当前位置： X-MOL 学术 › Adv. Funct. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Extracellular Matrix Remodelling: Obesity‐Associated Adipose Stromal Cells Promote Breast Cancer Invasion through Direct Cell Contact and ECM Remodeling (Adv. Funct. Mater. 48/2020)
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-11-25 , DOI: 10.1002/adfm.202070320
Lu Ling ₁ , Jeffrey A. Mulligan _{1,

2} , Yunxin Ouyang ₁ , Adrian A. Shimpi ₁ , Rebecca M. Williams ₃ , Garrett F. Beeghly ₁ , Benjamin D. Hopkins _{4,

5} , Jason A. Spector _{1,

6} , Steven G. Adie ₁ , Claudia Fischbach _{1,

7}

Affiliation

In article number 1910650, Claudia Fischbach and co‐workers combine collagen‐embedded multicellular spheroids and advanced imaging to investigate the effect of adipose stromal cells (ASCs) on tumor cell invasion as a function of obesity. Obese ASCs increase collective tumor cell migration relative to lean ASCs by stimulating proteolytic and contractility‐dependent collagen remode ling, providing insights into how obesity promotes breast cancer malignancy.

中文翻译：

细胞外基质重塑：肥胖相关的脂肪基质细胞通过直接细胞接触和ECM重塑促进乳腺癌侵袭（Adv。Funct。Mater。48/2020）

在编号1910650的文章中，Claudia Fischbach及其同事将胶原蛋白包埋的多细胞球体与先进的成像技术相结合，研究了肥胖引起的脂肪基质细胞（ASC）对肿瘤细胞侵袭的影响。相对于瘦ASC，肥胖ASC通过刺激蛋白水解和依赖于收缩力的胶原重塑而增加了集体肿瘤细胞迁移，从而提供了肥胖如何促进乳腺癌恶性肿瘤的见解。

更新日期：2020-11-25

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11