Peri-adolescent asthma: Acute impacts on innate immune response, corticosterone, and microglia in mice,Journal of Neuroimmunology

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Peri-adolescent asthma: Acute impacts on innate immune response, corticosterone, and microglia in mice
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.jneuroim.2020.577450
Jasmine I Caulfield ₁ , Kerri J Schopf ₂ , Sonia A Cavigelli ₁

Affiliation

Asthma is highly comorbid with anxiety in youth. We investigated the hypothalamic-pituitary-adrenal (HPA) axis and microglia as mechanisms underlying asthma and anxiety comorbidity. We induced asthma symptoms in developing BALB/cJ mice with house dust mite (HDM) for airway inflammation and methacholine (MCH) for bronchoconstriction. On the last day of exposure, we analyzed samples at six timepoints. Lung IL-5 and IL-1β expression peaked 4 h after final HDM exposure. Circulating corticosterone was blunted in a sex- and treatment-specific temporal pattern. Hippocampal IL-1β expression and microglial area were marginally increased 24 h after MCH exposure. These results provide a foundation for further work investigating asthma-anxiety mechanisms.

中文翻译：

青春期哮喘：对小鼠先天免疫反应、皮质酮和小胶质细胞的急性影响

青少年时期哮喘与焦虑高度共存。我们研究了下丘脑-垂体-肾上腺（HPA）轴和小胶质细胞作为哮喘和焦虑共病的机制。我们用屋尘螨 (HDM) 治疗气道炎症，用醋甲胆碱 (MCH) 治疗支气管收缩，在 BALB/cJ 小鼠中诱导哮喘症状。在暴露的最后一天，我们分析了六个时间点的样本。最终暴露于 HDM 后 4 小时，肺 IL-5 和 IL-1β 表达达到峰值。循环皮质酮以性别和治疗特异性时间模式减弱。 MCH 暴露后 24 小时，海马 IL-1β 表达和小胶质细胞面积略有增加。这些结果为进一步研究哮喘焦虑机制奠定了基础。

更新日期：2021-01-01

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