Abstract

Crosslinked cationic particles 200–600 nm in diameter have been synthesized via emulsifier-free copolymerization of methyl methacrylate and 2-aminoethyl methacrylate hydrochloride in the presence of cross-linking agents (N,N'-methylenebisacrylamide, triethylene glycol dimethacrylate, and diethylene glycol dimethacrylate). It has been shown that polymer particles with a maximum concentration of surface functional groups (1.42 µmol/m²) and a stable structure of a surface layer are formed only in the presence of ethanol (20 vol %). The synthesized particles efficiently adsorb biologically active substances, and their dispersions are stable against aggregation in buffer solutions at pH 7.0.

中文翻译：

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甲基丙烯酸甲酯基阳离子颗粒表面层结构对生物分子吸附的影响

摘要

交联的阳离子颗粒200-600的直径纳米已经通过甲基丙烯酸甲酯和2-氨基乙酯盐酸盐的交联剂（存在的无乳化剂的共聚合成Ñ，Ñ ' -亚甲基，三甘醇二甲基丙烯酸酯，和二甘醇二甲基）。已经表明，仅在乙醇（20体积％）存在下，形成具有最大表面官能团浓度（1.42μmol/ m ²）和表面层稳定结构的聚合物颗粒。合成的颗粒有效吸附生物活性物质，其分散液在pH 7.0的缓冲溶液中对聚集稳定。