We studied the effects of apoptotic bodies of cardiomyocytes (ApBc) and fibroblasts (ApBf) on myocardial regeneration and contractility in rats and the dynamics of RNA concentrations in cardiomyocytes and fibroblasts at different stages of apoptosis. ApBc increase the contractility of rat myocardium, while ApBf reduce it. ApBc stimulate the development of clones of cardiomyocyte precursors in the myocardium, while ApBf stimulate the formation of endothelial precursor clones. In doxorubicin cardiomyopathy, ApBc, similar to the reference drug (ACE inhibitor) improve animal survival, while ApBf produce no such effect. RNA concentrations in cardiomyocytes and fibroblasts before apoptosis and at the beginning of cell death significantly differed, while in apoptotic bodies of these cells, it was practically the same. It has been hypothesized that RNA complex present in ApBc and ApBf represents an "epigenetic code" of directed differentiation of cardiac stem cells.

中文翻译：

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心肌细胞和成纤维细胞的凋亡小体——心脏干细胞定向分化的调节剂

我们研究了心肌细胞 (ApBc) 和成纤维细胞 (ApBf) 的凋亡小体对大鼠心肌再生和收缩力的影响，以及不同凋亡阶段心肌细胞和成纤维细胞中 RNA 浓度的动态变化。ApBc 增加大鼠心肌的收缩力，而 ApBf 降低它。ApBc 刺激心肌中心肌细胞前体克隆的发育，而 ApBf 刺激内皮前体克隆的形成。在多柔比星心肌病中，ApBc 与参考药物（ACE 抑制剂）相似，可提高动物存活率，而 ApBf 没有这种作用。在细胞凋亡前和细胞死亡开始时，心肌细胞和成纤维细胞中的 RNA 浓度显着不同，而在这些细胞的凋亡小体中，它实际上是相同的。