Objective: Myonectin, a newly discovered myokine, enhances fatty acid uptake in cultured adipocytes and hepatocytes and suppresses circulating levels of free fatty acids in mice. This study is performed to evaluate the association between serum myonectin concentrations with the presence and severity of OSAS.

Methods: This study was performed in a population of 191 patients with OSAS and 105 control subjects. Serum myonectin concentrations were measured using enzyme-linked immunosorbent assay method.

Results: Lower serum myonectin concentrations were found in OSAS patients than in the controls. Serum myonectin concentrations were associated with a reduced risk of OSAS (OR: 0.988, 95% CI: 0.984-0.993, P<0.001). Severe OSAS patients had significantly lower myonectin concentrations compared with mild and moderate OSAS patients (P<0.001 and P=0.001, respectively). There are lower serum myonectin concentrations in moderate patients compared with mild patients (P=0.024). Pearson correlation analysis revealed that serum myonectin concentrations were negatively correlated with the severity of OSAS (r=-0.344, P<0.001). Simple linear regression analysis showed that serum myonectin concentrations in OSAS patients were negatively correlated with body mass index (BMI), fasting plasma glucose, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and apnea hypopnea index (AHI). Multiple stepwise regression analysis shows that BMI (β=-0.289, P=0.03), HOMA-IR (β=-0.19, P=0.003), TC (β=-0.155, P=0.016), LDL-C (β=-0.176, P=0.006), and AHI (β=-0.263, P<0.001) remained to be associated with serum myonectin.

Conclusion: Serum myonectin concentrations are inversely correlated with the presence and severity of OSAS.

目的：一种新发现的肌动蛋白，肌粘连蛋白，能增加培养的脂肪细胞和肝细胞中脂肪酸的摄取，并抑制小鼠体内游离脂肪酸的循环水平。进行这项研究是为了评估血清肌连蛋白浓度与OSAS的存在和严重程度之间的关系。

方法：本研究在191名OSAS患者和105名对照受试者中进行。使用酶联免疫吸附测定法测量血清中肌连蛋白的浓度。

结果：与对照组相比，OSAS患者血清中的肌连蛋白浓度更低。血清肌连蛋白浓度与OSAS风险降低相关（OR：0.988，95％CI：0.984-0.993，P <0.001）。与轻度和中度OSAS患者相比，重度OSAS患者的肌连蛋白浓度显着降低（分别为P <0.001和P = 0.001）。与轻度患者相比，中度患者血清中的肌粘连蛋白浓度较低（P = 0.024）。皮尔逊相关分析显示，血清中肌粘连蛋白浓度与OSAS严重程度呈负相关（r = -0.344，P <0.001）。简单的线性回归分析显示，OSAS患者的血清肌连蛋白浓度与体重指数（BMI），空腹血糖，胰岛素抵抗（HOMA-IR），总胆固醇（TC），低密度脂蛋白胆固醇（LDL-C）和呼吸暂停低通气指数（AHI）的稳态模型评估。多个逐步回归分析显示，BMI（β= -0.289，P = 0.03），HOMA-IR（β= -0.19，P = 0.003），TC（β= -0.155，P = 0.016），LDL-C（β= -0.176，P = 0.006）和AHI（β= -0.263，P <0.001）仍与血清肌连蛋白有关。

结论：血清肌连蛋白浓度与OSAS的存在和严重程度成反比。