Poly (lactic acid)/lignin nanocomposites (PLA/Lig-Np) containing cinnamaldehyde (Ci) were obtained by a combination of melt extrusion and supercritical impregnation process. In this work, Ci impregnation tests were carried out in a high-pressure cell at 40 °C for 3 h using 12 MPa and 1 MPa min⁻¹ of depressurization rate, obtaining impregnation yields ranging from 5.7 to 10.8% w/w. Thermal, mechanical and colorimetric properties of the developed films were affected by the incorporation of lignin nanoparticles and the active compound, obtaining biodegradable plastic materials with a strong UV-light barrier property compared to PLA films. In addition, disintegrability tests under composting conditions confirmed the biodegradable character of nanocomposites developed. On day 23, a disintegration percentage greater than 90% was determined for all bionanocomposites. Finally, to establish the possible toxicity effect of the nanocomposites obtained, studies in vivo were performed in normal rats. Toxicity studies showed normal blood parameters after a single dose of nanocomposites. PLA/Ci/Lig-Np bionanocomposite films could be potentially applied to design biodegradable UV-light barrier materials for food packaging and biomedical applications.

通过熔融挤出和超临界浸渍工艺相结合，获得了含有肉桂醛（Ci）的聚乳酸/木质素纳米复合材料（PLA / Lig-Np）。在这项工作中，在40°C的高压电池中使用12 MPa和1 MPa min ^-1进行Ci浸渍测试3 h。的减压速率，获得的浸渍产率为5.7至10.8％w / w。木质素纳米颗粒和活性化合物的加入会影响显影膜的热，机械和比色性能，从而获得与PLA膜相比具有较强的紫外线阻隔性能的可生物降解塑料。另外，在堆肥条件下的崩解性测试证实了所开发的纳米复合材料的生物可降解特性。在第23天，对于所有生物纳米复合材料，崩解百分数确定为大于90％。最后，为了确定获得的纳米复合材料可能的毒性作用，在正常大鼠中进行了体内研究。毒性研究表明，单剂纳米复合物给药后血液参数正常。