In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09–1.22 ± 0.13 mm by crosslinking with FeCl₃ and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug. The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent. Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM). It was observed that IBU-loaded beads displayed better release performance with an increase amount of NaAlg in the structure. Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl₃ concentration of 0.1 M, and crosslinking time of 90 min. The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.

在这项研究中，通过与FeCl ₃交联，将藻酸钠（NaAlg）和甲基纤维素（MC）的离子交联珠制备为半互穿聚合物网络（semi-IPN），尺寸范围为1.97±0.09–1.22±0.13 mm。并装有布洛芬（IBU），这是一种非甾体类抗炎药。IBU的包封率最高，达到了93.33％，并根据聚合物的组成，布洛芬与聚合物的比例，与交联剂的接触时间以及异丙醇的浓度对微珠的药物释放行为，平均粒径和包封率进行了研究。交联剂。还使用傅立叶变换红外（FTIR）光谱，差示扫描量热法（DSC），X射线衍射（X-RD）和扫描电子显微镜（SEM）对制备的半IPN制剂进行了表征。观察到，随着结构中NaAlg含量的增加，装载IBU的珠粒显示出更好的释放性能。最后，对于含有66.7％（w / w）NaAlg，33.3％（w / w）MC，₃浓度为0.1M，交联时间为90分钟。体外释放速率与五个经验方程拟合，扩散指数为n，表明IBU从珠粒的释放机理遵循异常和Case II转运机理。