Abstract Bone tissue engineering is one of the important treatment methods for bone defects, especially relatively large bone defects. A variety of design strategies have been developed to obtain bone tissue scaffolds. The development of scaffolds equipped with more functions can provide more options for the treatment of bone defects, which, however, remains a challenge. Here, we introduce 3D printed porous bone tissue scaffolds based on shape memory polymer composite (SMPC). The designs are proposed based on thorough observation and analysis of the microstructure of lotus root and cellular co-continuous-like structures. Moreover, the addition of magnetic nanoparticles endows the scaffolds with the ferromagnetic domains, which opens up an opportunity to implant bone tissue scaffolds into the body in a contracted state and make them a perfect match. The experimental and micromechanical theoretical studies of the mechanical properties illustrate the reliability of the structures, while the biological experiments verify the biological activity and osteogenic effect of these scaffolds. The shape memory effect suggests potential advantages in minimally invasive surgery. These porous scaffolds based on SMPC are expected to be applied to the repair and regeneration of bone tissue.

中文翻译：

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基于形状记忆 PLA/Fe3O4 的多孔骨组织支架概念

摘要 骨组织工程是骨缺损尤其是较大骨缺损的重要治疗手段之一。已经开发了多种设计策略来获得骨组织支架。具有更多功能的支架的开发可以为骨缺损的治疗提供更多选择，但这仍然是一个挑战。在这里，我们介绍了基于形状记忆聚合物复合材料 (SMPC) 的 3D 打印多孔骨组织支架。这些设计是基于对莲藕和蜂窝状共连续结构的微观结构的彻底观察和分析而提出的。此外，磁性纳米粒子的加入使支架具有铁磁畴，这为将骨组织支架以收缩状态植入体内并使其完美匹配提供了机会。力学性能的实验和微观力学理论研究说明了结构的可靠性，而生物学实验验证了这些支架的生物活性和成骨作用。形状记忆效应表明微创手术具有潜在优势。这些基于 SMPC 的多孔支架有望应用于骨组织的修复和再生。