Promoting bone regeneration to treat bone defects is a challenging problem in orthopedics, and developing novel biomaterials with both osteogenic and angiogenic activities is sought as a feasible solution. Here, copper-silicocarnotite [Cu–Ca₅(PO₄)₂SiO₄, Cu-CPS] was designed and fabricated. In this study, the Cu-CPS ceramics demonstrated better mechanical, osteogenic, and angiogenic properties in vitro and in vivo than pure CPS one. Particularly, CPS with 1.0 wt% CuO (1.0Cu-CPS) exhibited the best performance. Additionally, hydroxyapatite with 1.0 wt% CuO (1.0Cu-HA) was used to explore the respective effects of copper and silicon (Si). According to the in vitro results, it indicated that Cu enhanced the osteogenic activity of CPS ceramics although Si played a dominate role in the osteogenic process. Moreover, Cu could promote an early stage of angiogenesis, and the complementary effect of Si and Cu was found in the late phase. Furthermore, the in vivo results illustrated that the synergistic effect of Cu and Si improved bone and vessel regeneration during the degradation of Cu-CPS scaffolds (P < 0.05). Therefore, Cu-CPS ceramics could improve osteogenesis and angiogenesis through the simultaneous effects of Cu and Si, thus, offering a promising treatment option in orthopedic application for bone tissue regeneration.

在骨科中，促进骨再生以治疗骨缺损是一个具有挑战性的问题，寻求开发具有成骨和血管生成活性的新型生物材料是一种可行的解决方案。在这里，设计并制造了铜硅碳钙石[Cu-Ca ₅（PO ₄）₂ SiO ₄，Cu-CPS]。在这项研究中，Cu-CPS陶瓷在体外和体内显示出比纯CPS更好的机械，成骨和血管生成性能。特别地，具有1.0wt％的CuO（1.0Cu-CPS）的CPS表现出最好的性能。此外，使用含1.0 wt％CuO（1.0Cu-HA）的羟基磷灰石来研究铜和硅（Si）的相应作用。根据体外结果表明，尽管Si在成骨过程中起着主要作用，但Cu增强了CPS陶瓷的成骨活性。而且，铜可以促进血管新生的早期，并且在后期发现硅和铜的互补作用。此外，体内结果表明，在Cu-CPS支架降解过程中，Cu和Si的协同作用改善了骨骼和血管的再生（P <0.05）。因此，Cu-CPS陶瓷可以通过Cu和Si的同时作用来改善成骨和血管生成，从而为骨科再生骨科应用提供了有希望的治疗选择。