Summary Biomphalaria alexandrina snails have received much attention due to their great medical importance as vectors for transmitting Schistosoma mansoni infection to humans. The main objective of the present work was to assess the efficacy of miltefosin a synthetic molluscicidal drug and artemether a natural molluscicidal drug. The correlation between immunological and histological observations from light and electron microscopy of the hemocytes of B. alexandrina post treatment with both drugs was also evaluated. LC50 and LC90 values were represented by 13.80 ppm and 24.40 ppm for miltefosine and 16.88 ppm and 27.97 ppm for artemether, respectively. The results showed that the treatment of S. mansoni-infected snails and normal snails with sublethal dose of miltefosine (LC25=8.20 ppm) and artemether (LC25=11.04 ppm) induced morphological abnormalities and a significant reduction in hemocytes count.

中文翻译：

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米替福辛和蒿甲醚对感染曼氏血吸虫的亚历山大双脐螺的功效：免疫学和组织学研究


摘要 双脐螺因其作为将曼氏血吸虫感染传播给人类的媒介而具有巨大的医学重要性而受到广泛关注。本工作的主要目的是评估合成杀软体动物药物米替福辛和天然杀软体动物药物蒿甲醚的功效。还评估了用两种药物治疗后亚历山大拟杆菌血细胞的光学和电子显微镜观察的免疫学和组织学观察之间的相关性。米替福辛的 LC50 和 LC90 值分别为 13.80 ppm 和 24.40 ppm，蒿甲醚的 LC50 和 LC90 值分别为 16.88 ppm 和 27.97 ppm。结果表明，用亚致死剂量的米替福辛（LC25=8.20 ppm）和蒿甲醚（LC25=11.04 ppm）处理曼氏链螺和正常蜗牛，可引起形态异常和血细胞计数显着减少。