Purpose

To examine the relationship between lid margin abnormalities and meibomian gland loss in infrared meibography.

Methods

This study was a retrospective chart review of 170 patients with dry eye disease. A correlation analysis between eyelid margin abnormalities and meibomian gland dropout in infrared meibography was performed using data from 141 eyes. We graded the following eyelid margin abnormalities: irregular lid margin, vascular engorgement, plugging, anterior placement of the mucocutaneous junction, exposed terminal duct, and presence of tattoos. Multiple regression analyses were performed with meiboscore (meibomian gland dropout grade) as the dependent variable and age, sex, lid margin abnormality grades, and total grading score of lid margin abnormalities as the covariates. In addition, Meibomian glands structure were examined in those with eyelid margin dimpling using meibography in 25 eyes.

Results

In the multiple regression analysis, an irregular lid margin in the upper eyelid was associated with a higher meiboscore after controlling for age and sex (coefficients B = 1.379, p = 0.025). Other lid margin abnormalities did not significantly affect the meiboscore. In the lower eyelids, irregular lid margin (coefficients B = 0.602, p = 0.009) and total grading score of lid margin abnormality were associated with higher meiboscores (coefficients B = 0.100, p = 0.022). Of the 25 eyes with dimples, 21 (84%) showed focal or complete meibomian gland loss at the site.

Conclusions

Lid margin abnormalities were found to be associated with meibomian gland dropout.

中文翻译：

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眼睑边缘不规则与睑板腺脱落的关系

目的

要检查的红外热像仪睑缘异常和睑板腺损失之间的关系。

方法

这项研究是对170例干眼症患者的回顾性图表回顾。使用来自141只眼睛的数据进行了红外X线摄影术中眼睑边缘异常与睑板腺脱落之间的相关性分析。我们对以下眼睑边缘异常进行了分级：不规则的眼睑边缘，血管充血，堵塞，粘膜皮肤交界处的前部放置，暴露的末端导管和纹身的存在。进行多元回归分析，以meiboscore（睑板腺脱落评分）作为因变量，以年龄，性别，眼睑边缘异常等级和眼睑边缘异常总评分作为协变量。另外，在25只眼中，通过睑板造影检查了睑缘凹陷处的睑板腺结构。

结果

在多元回归分析中，在控制了年龄和性别之后，上眼睑的不规则眼睑边缘与更高的睑裂评分相关（系数B = 1.379，p  = 0.025）。其他眼睑边缘异常并未明显影响meiboscore。在下眼睑中，不规则的 睑缘（系数B = 0.602，p = 0.009）和睑缘异常的总评分得分与较高的睑板评分相关（系数B = 0.100，p  = 0.022）。在25个有酒窝的眼睛中，有21个（84％）在该部位表现出局灶性或完全性睑板腺丧失。

结论

发现盖缘异常与睑板腺脱落有关。