The unprecedented scale of the ongoing COVID-19 pandemic has catalyzed an intense effort of the global scientific community to unravel different aspects of the disease in a short time. One of the crucial aspects of these developments is the determination of more than three hundred experimental structures of SARS-CoV-2 proteins in the last few months. These include structures of viral non-structural, structural, and accessory proteins and their complexes determined by either X-ray diffraction or cryo-electron microscopy. These structures elucidate the intricate working of different components of the viral machinery at the atomic level during different steps of the viral life cycle, including attachment to the host cell, viral genome replication and transcription, and genome packaging and assembly of the virion. Some of these proteins are also potential targets for drug development against the disease. In this review, we discuss important structural features of different SARS-CoV-2 proteins with their function, and their potential as a target for therapeutic interventions.

正在发生的新冠肺炎 (COVID-19) 疫情规模空前，促使全球科学界做出巨大努力，试图在短时间内解开该疾病的不同方面。这些进展的关键方面之一是在过去几个月中确定了 300 多个 SARS-CoV-2 蛋白的实验结构。其中包括病毒非结构蛋白、结构蛋白和辅助蛋白的结构及其通过 X 射线衍射或冷冻电子显微镜测定的复合物。这些结构在病毒生命周期的不同步骤中阐明了病毒机器不同组件在原子水平上的复杂工作，包括附着于宿主细胞、病毒基因组复制和转录、以及病毒粒子的基因组包装和组装。其中一些蛋白质也是针对该疾病的药物开发的潜在靶标。在这篇综述中，我们讨论了不同 SARS-CoV-2 蛋白的重要结构特征及其功能，以及它们作为治疗干预目标的潜力。