Molecularly imprinted polymers (MIPs) are a fascinating technology for the sensitive and selective detection of target molecules. However, in most situations, the need for complicated and expensive analytical devices for reading the responses of MIPs greatly limits their applications. For exploring low-cost and easy-to-use applications of MIPs, herein we have developed a MIP-modified extended-gate type organic field-effect transistor (MIP-OFET). Taurine was selected as a demonstrative analyte due to its biological roles and utility as a nutrient. We explored the rational design of the novel MIP with the aid of density functional theory and wave function calculations and characterized the electrochemically synthesized MIP using differential pulse voltammetry and electrochemical impedance spectroscopy. The mechanism of taurine detection by the MIP-OFET can be explained by the changes in the surface potential of the MIP-functionalized extended-gate electrode accompanied with the capture of taurine. The detection limit of taurine in complete aqueous media was estimated to be 0.33 μM, which was lower or comparable to those calculated by high-performance liquid chromatography. Furthermore, taurine in a commercial drink without any extraction was also successfully detected using the fabricated MIP-OFET. This study would broaden the scope of the applications of MIP-OFETS as chemical sensors for on-site detection of various daily nutrients.

中文翻译：

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分子印迹聚合物功能化的牛磺酸检测用扩展栅型有机晶体管

分子印迹聚合物（MIP）是一种用于灵敏和选择性检测目标分子的引人入胜的技术。但是，在大多数情况下，对用于读取MIP响应的复杂且昂贵的分析设备的需求极大地限制了其应用。为了探索MIP的低成本和易于使用的应用，我们在这里开发了一种MIP改进的扩展栅型有机场效应晶体管（MIP-OFET）。牛磺酸由于其生物学作用和作为营养物的用途而被选作示范分析物。我们借助密度泛函理论和波函数计算探索了新型MIP的合理设计，并使用差分脉冲伏安法和电化学阻抗谱对电化学合成的MIP进行了表征。MIP-OFET检测牛磺酸的机理可以通过伴随着牛磺酸捕获的MIP功能化扩展栅电极的表面电势变化来解释。牛磺酸在完全水性介质中的检出限估计为0.33μM，低于或与通过高效液相色谱法计算的检出限相当。此外，使用制造的MIP-OFET还成功地检测了没有提取的市售饮料中的牛磺酸。这项研究将扩大MIP-OFETS作为现场检测各种日常营养的化学传感器的应用范围。牛磺酸在完全水性介质中的检出限估计为0.33μM，低于或与通过高效液相色谱法计算的检出限相当。此外，使用制造的MIP-OFET还成功地检测了没有提取的市售饮料中的牛磺酸。这项研究将扩大MIP-OFETS作为现场检测各种日常营养的化学传感器的应用范围。牛磺酸在完全水性介质中的检出限估计为0.33μM，低于或与通过高效液相色谱法计算的检出限相当。此外，使用制造的MIP-OFET还成功地检测了没有提取的市售饮料中的牛磺酸。这项研究将扩大MIP-OFETS作为现场检测各种日常营养的化学传感器的应用范围。