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Toxicokinetics of pristine and aged silver nanoparticles in Physa acuta
Environmental Science: Nano ( IF 5.8 ) Pub Date : 2020-11-11 , DOI: 10.1039/d0en00946f Patrícia V. Silva 1, 2, 3, 4 , Cornelis A. M. van Gestel 5, 6, 7, 8 , Rudo A. Verweij 5, 6, 7, 8 , Anastasios G. Papadiamantis 9, 10, 11, 12, 13 , Sandra F. Gonçalves 1, 2, 3, 4 , Iseult Lynch 9, 10, 11, 12 , Susana Loureiro 1, 2, 3, 4
Environmental Science: Nano ( IF 5.8 ) Pub Date : 2020-11-11 , DOI: 10.1039/d0en00946f Patrícia V. Silva 1, 2, 3, 4 , Cornelis A. M. van Gestel 5, 6, 7, 8 , Rudo A. Verweij 5, 6, 7, 8 , Anastasios G. Papadiamantis 9, 10, 11, 12, 13 , Sandra F. Gonçalves 1, 2, 3, 4 , Iseult Lynch 9, 10, 11, 12 , Susana Loureiro 1, 2, 3, 4
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Aquatic environments, particularly sediments, can be important final sinks for engineered nanoparticles (ENPs), with benthic biota being potentially exposed. There is an increasing need for hazard data to improve the environmental risk assessment of ENPs regarding aquatic systems. The aim of this study was to determine the toxicokinetics of several pristine (as manufactured) Ag-NPs, Ag2S-NPs (used to simulate environmental aging of silver nanoparticles) and AgNO3 as the ionic counterpart, in the freshwater snail Physa acuta. Snails were exposed through 1) contaminated water (without sediment), 2) contaminated water and clean sediment, and 3) contaminated sediment. Bioavailability of Ag to the snails was greatly influenced by Ag characteristics, as different uptake and elimination kinetics were found for the different Ag forms within the same exposure route. Snails exposed via water revealed, in general, similar uptake kinetics, differing from exposure via contaminated sediment, suggesting that exposure route also had a determining role in Ag bioavailability. The simulated aged form (Ag2S-NPs) revealed fast uptake and depuration in snails from all experiments. When considering the double exposure route, which provides a more realistic contamination scenario, water was the main route, except for Ag2S-NPs, for which sediment was more important. The remarkably low elimination and high stored fraction of Ag in some exposures emphasizes the bioaccumulation ability of P. acuta and may raise concerns about possible trophic transfer. Snail shells accumulated low amounts of Ag. The present study highlights the need for a proper examination of the overall exposure scenario of Ag-NPs to benthic organisms. Our results contribute to the environmental risk assessment of Ag-NPs in benthic environments.
中文翻译：
原始和老化银纳米粒子在毒死cut中的毒代动力学
水生环境，特别是沉积物，可能是工程化纳米颗粒（ENP）的重要最终汇，底栖生物可能被暴露。对危害数据的需求日益增加，以改善有关水生系统的ENP的环境风险评估。这项研究的目的是确定淡水蜗牛Physa acuta中几种原始的（已生产的）Ag-NP，Ag 2 S-NP（用于模拟银纳米粒子的环境老化）和作为离子对应物的AgNO 3的毒代动力学。。通过1）污染的水（没有沉淀物），2）污染的水和干净的沉淀物以及3）污染的泥土来暴露蜗牛。银在蜗牛上的生物利用度受银的特性影响很大，因为在相同的暴露途径下，不同的银形式发现了不同的吸收和消除动力学。通常，通过水暴露的蜗牛显示出相似的吸收动力学，不同于通过受污染的沉积物暴露的蜗牛，这表明暴露途径对Ag生物利用度也具有决定性作用。模拟的老化形式（Ag 2S-NPs）揭示了所有实验中蜗牛的快速摄取和净化作用。当考虑提供更现实的污染情况的二次暴露途径时，水是主要途径，除了Ag 2 S-NPs，沉积物更重要。在某些暴露条件下，Ag的极低消除和高存储分数强调了褐角假单胞菌的生物蓄积能力，并可能引起人们对可能的营养转移的担忧。蜗牛壳积聚了少量的银。本研究强调需要适当检查Ag-NPs对底栖生物的总体暴露情况。我们的结果有助于在底栖环境中评估Ag-NP的环境风险。
更新日期：2020-11-25
中文翻译：
原始和老化银纳米粒子在毒死cut中的毒代动力学
水生环境，特别是沉积物，可能是工程化纳米颗粒（ENP）的重要最终汇，底栖生物可能被暴露。对危害数据的需求日益增加，以改善有关水生系统的ENP的环境风险评估。这项研究的目的是确定淡水蜗牛Physa acuta中几种原始的（已生产的）Ag-NP，Ag 2 S-NP（用于模拟银纳米粒子的环境老化）和作为离子对应物的AgNO 3的毒代动力学。。通过1）污染的水（没有沉淀物），2）污染的水和干净的沉淀物以及3）污染的泥土来暴露蜗牛。银在蜗牛上的生物利用度受银的特性影响很大，因为在相同的暴露途径下，不同的银形式发现了不同的吸收和消除动力学。通常，通过水暴露的蜗牛显示出相似的吸收动力学，不同于通过受污染的沉积物暴露的蜗牛，这表明暴露途径对Ag生物利用度也具有决定性作用。模拟的老化形式（Ag 2S-NPs）揭示了所有实验中蜗牛的快速摄取和净化作用。当考虑提供更现实的污染情况的二次暴露途径时，水是主要途径，除了Ag 2 S-NPs，沉积物更重要。在某些暴露条件下，Ag的极低消除和高存储分数强调了褐角假单胞菌的生物蓄积能力，并可能引起人们对可能的营养转移的担忧。蜗牛壳积聚了少量的银。本研究强调需要适当检查Ag-NPs对底栖生物的总体暴露情况。我们的结果有助于在底栖环境中评估Ag-NP的环境风险。
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