Nickel-catalysed chemoselective C-3 alkylation of indoles with alcohols through a borrowing hydrogen method,Chemical Communications

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Nickel-catalysed chemoselective C-3 alkylation of indoles with alcohols through a borrowing hydrogen method
Chemical Communications ( IF 4.3 ) Pub Date : 2020-11-11 , DOI: 10.1039/d0cc07169b
Amreen K. Bains _{1,

2,

3,

4,

5} , Ayanangshu Biswas _{1,

2,

3,

4,

5} , Debashis Adhikari _{1,

2,

3,

4,

5}

Affiliation

An inexpensive, air-stable, isolable nickel catalyst is reported that can perform chemoselective C3-alkylation of indoles with a variety of alcohols following “borrowing hydrogen”. A one-pot, cascade C3-alkylation starting from 2-aminophenyl ethyl alcohols, and thus obviating the need for pre-synthesized indoles, further adds to the broad scope of this method. The reaction is radical-mediated, and is significantly different from other examples, often dictated by metal–ligand bifunctionality.

中文翻译：

通过借位氢法用醇催化镍催化的吲哚与醇的化学选择C-3烷基化

据报道，一种廉价的，空气稳定的，可分离的镍催化剂可在“借入氢”后与多种醇进行吲哚的化学选择性C3-烷基化。从2-氨基苯基乙醇开始的一锅级联C3-烷基化反应，从而消除了对预合成的吲哚的需要，进一步扩大了该方法的范围。该反应是自由基介导的，与其他例子有显着差异，通常由金属-配体双官能度决定。

更新日期：2020-11-25

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