Simultaneous detection and speciation of mono- and di-valent copper ions with a dual-channel fluorescent nanoprobe,Chemical Communications

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Simultaneous detection and speciation of mono- and di-valent copper ions with a dual-channel fluorescent nanoprobe
Chemical Communications ( IF 4.3 ) Pub Date : 2020-11-10 , DOI: 10.1039/d0cc06750d
An-Qi Zheng _{1,

2,

3,

4,

5} , Chen-Xi Zhao _{1,

2,

3,

4,

5} , Xiao-Juan Wang _{1,

2,

3,

4,

5} , Yang Shu _{1,

2,

3,

4,

5} , Jian-Hua Wang _{1,

2,

3,

4,

5}

Affiliation

Redox cyclings between mono-/di-valent copper oxidation states occur in electron transfer reactions that underlie their biological functions. We report herein a dual channel fluorescent nanoprobe for the detection of mono- and di-valent copper ions. The probe, BSA-CDs@RBH/BCS, is designed by decorating carbon dots (CDs) on BSA encapsulated rhodamine hydrazide (RBH) and conjugating with bathocuproine disulfonate (BCS). Cu²⁺ catalyzes the hydrolysis of RBH, and the formed rhodamine B (RhB) shows emission at λ_ex/λ_em = 360/575 nm which ensures Cu²⁺ detection. BSA reduces Cu²⁺ to Cu⁺ and the BCS–Cu⁺ chelate shows emission at λ_ex/λ_em 360/450 nm which ensures Cu⁺ assay. Thus, the dual-channel fluorescence enables speciation of Cu²⁺ and Cu⁺.

中文翻译：

使用双通道荧光纳米探针同时检测和分析一价和二价铜离子

一价/二价铜氧化态之间的氧化还原循环发生在电子转移反应中，这是其生物学功能的基础。我们在此报告了一种用于检测单价和二价铜离子的双通道荧光纳米探针。探针BSA-CDs @ RBH / BCS是通过在BSA封装的罗丹明酰肼（RBH）上修饰碳点（CD）并与浴嘌呤二磺酸盐（BCS）结合而设计的。的Cu ²⁺催化RBH的水解，所形成的若丹明B色在（罗丹明B）示出了发射λ _EX / λ _EM =五百七十五分之三百六纳米这确保铜²⁺检测。BSA将Cu ²⁺还原为Cu ⁺，而BCS–Cu ⁺螯合物在λ _EX / λ _EM四百五分之三百六纳米这确保铜⁺测定。因此，双通道荧光使得能够形成Cu ²⁺和Cu ⁺。

更新日期：2020-11-25

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