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Biomaterial strategies to replicate gynecological tissue
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-11-19 , DOI: 10.1039/d0bm01240h Ines Cadena 1, 2, 3, 4, 5 , Athena Chen 6, 7, 8, 9, 10 , Aaron Arvidson 1, 2, 3, 4, 5 , Kaitlin C. Fogg 1, 2, 3, 4, 5
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-11-19 , DOI: 10.1039/d0bm01240h Ines Cadena 1, 2, 3, 4, 5 , Athena Chen 6, 7, 8, 9, 10 , Aaron Arvidson 1, 2, 3, 4, 5 , Kaitlin C. Fogg 1, 2, 3, 4, 5
Affiliation
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Women's health is an important and understudied area of research. The current standard of care for many gynecological diseases such as cancer or autoimmune-linked disorders such as endometriosis is surgery; however, the underlying mechanisms of action of many gynecological diseases are poorly understood. The field of tissue engineering has the potential to transform the field of women's health by developing in vitro models of healthy and diseased tissue that could be used to identify novel treatment strategies as well as gain a better understanding of complex signaling dynamics. Identification of the appropriate biomaterials, cell types, and stimuli (the tissue engineering triad) needed to build these in vitro models can be gleaned by interrogating the underlying extracellular matrix, cell organization, and soluble factors present in the tissue. In this review, we provide a general overview of the biology and components of the major tissues that make up the female reproductive system (ovaries, fallopian tubes, the uterus, and cervix) as well as a comprehensive survey of the different biomaterials that have been chosen to build in vitro models of these tissues. Furthermore, for each tissue, we recommend guiding principles in the design of in vitro models and discuss their potential to be used in drug screening and mechanistic studies.
中文翻译：
复制妇科组织的生物材料策略
妇女的健康是一个重要且未被研究的领域。对于许多妇科疾病（例如癌症）或自身免疫相关疾病（例如子宫内膜异位症）的当前护理标准是手术；然而，人们对许多妇科疾病的潜在作用机理了解甚少。组织工程学领域有潜力通过开发健康和患病组织的体外模型来转变女性健康领域，该模型可用于识别新的治疗策略以及更好地理解复杂的信号动力学。鉴定构建体外所需的适当生物材料，细胞类型和刺激物（组织工程三联体）可以通过询问组织中存在的基础细胞外基质，细胞组织和可溶性因子来收集模型。在这篇综述中，我们提供了组成女性生殖系统的主要组织（卵巢，输卵管，子宫和子宫颈）的生物学和组成部分的一般概述，以及对已经形成的不同生物材料的全面调查。选择建立这些组织的体外模型。此外，对于每种组织，我们建议设计体外模型的指导原则，并讨论其在药物筛选和机理研究中的潜力。
更新日期：2020-12-16
中文翻译：
复制妇科组织的生物材料策略
妇女的健康是一个重要且未被研究的领域。对于许多妇科疾病（例如癌症）或自身免疫相关疾病（例如子宫内膜异位症）的当前护理标准是手术；然而，人们对许多妇科疾病的潜在作用机理了解甚少。组织工程学领域有潜力通过开发健康和患病组织的体外模型来转变女性健康领域，该模型可用于识别新的治疗策略以及更好地理解复杂的信号动力学。鉴定构建体外所需的适当生物材料，细胞类型和刺激物（组织工程三联体）可以通过询问组织中存在的基础细胞外基质，细胞组织和可溶性因子来收集模型。在这篇综述中，我们提供了组成女性生殖系统的主要组织（卵巢，输卵管，子宫和子宫颈）的生物学和组成部分的一般概述，以及对已经形成的不同生物材料的全面调查。选择建立这些组织的体外模型。此外，对于每种组织，我们建议设计体外模型的指导原则，并讨论其在药物筛选和机理研究中的潜力。
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