Aquaporins (AQPs), small hydrophobic integral membrane proteins, mediate rapid transport of water and small solutes. The abnormal expressions of AQPs are associated with pregnancy complications and reproductive dysfunctions, including preeclampsia, gestational diabetes mellitus, tubal ectopic pregnancy, intrahepatic cholestasis of pregnancy, preterm birth, chorioamnionitis, polyhydramnios, and oligohydramnios, thus resulting in adverse pregnancy outcomes. This review explains the alterations of AQPs in pregnancy complications and reproductive dysfunctions and summarizes the molecular mechanisms involved in the regulations of AQPs by drugs such as oxytocin, polychlorinated biphenyls, all-trans-retinoic acid, salvia miltiorrhiza, and insulin, or other factors such as oxygen and osmotic pressure. All the research provides evidence that AQPs could be the new therapeutic targets of pregnancy-related diseases.

中文翻译：

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水通道蛋白在妊娠并发症和生殖功能障碍中的表达和调控

水通道蛋白（AQP）是小的疏水性完整膜蛋白，可介导水和小的溶质的快速运输。AQPs的异常表达与妊娠并发症和生殖功能障碍有关，包括先兆子痫，妊娠糖尿病，输卵管异位妊娠，妊娠肝内胆汁淤积，早产，脉络膜羊膜炎，羊水过多和羊水过少，从而导致不良的妊娠结局。这篇综述解释了妊娠并发症和生殖功能障碍中AQP的改变，并总结了催产素，多氯联苯，全反式维甲酸，丹参和胰岛素等药物对AQP调节的分子机制。作为氧气和渗透压。