Citronamine A, an Antiplasmodial Isoquinoline Alkaloid from the Australian Marine Sponge Citronia astra,Organic Letters

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Citronamine A, an Antiplasmodial Isoquinoline Alkaloid from the Australian Marine Sponge Citronia astra
Organic Letters ( IF 4.9 ) Pub Date : 2020-11-24 , DOI: 10.1021/acs.orglett.0c03633
Dale W Prebble _{1,

2,

3} , Darren C Holland _{1,

2} , Luke P Robertson _{1,

2} , Vicky M Avery _{3,

4} , Anthony R Carroll _{1,

2,

3}

Affiliation

Citronamine A (1), an isoquinoline alkaloid containing an unprecedented pentacyclic ring system, was isolated from the Australian marine sponge Citronia astra. Based on the combination of MS and NMR analyses and comparison of experimental and TDDFT calculated ECD spectra, the absolute structure of 1 was determined. Compound 1 displayed moderate activity against drug sensitive (3D7) and drug resistant (Dd2) strains of the parasite, Plasmodium falciparum, responsible for malaria.

中文翻译：

Citronamine A，一种来自澳大利亚海洋海绵 Citronia astra 的抗疟原虫异喹啉生物碱

Citronamine A ( 1 ) 是一种异喹啉生物碱，含有前所未有的五环系统，是从澳大利亚海洋海绵Citronia astra 中分离出来的。基于 MS 和 NMR 分析的组合以及实验和 TDDFT 计算的 ECD 光谱的比较，确定了1的绝对结构。化合物1对引起疟疾的寄生虫恶性疟原虫的药物敏感 (3D7) 和耐药 (Dd2) 菌株表现出中等活性。

更新日期：2020-12-18

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