Prorocentroic acid (PA) was isolated from the dinoflagellate Prorocentrum hoffmannianum. Relative configurations for its 35 asymmetric centers were determined by analysis of NMR data including heteronuclear couplings and quantum mechanical calculations. PA was tested by using murine cortical neurons grown on microelectrode arrays. Long-term exposure to subtoxic concentrations induced a significant reorganization of neuronal signaling, mainly by changes in the bursting activity. The observed effects could be due to the activation of a plasticity process.

中文翻译：

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Prorocentroic Acid，一种来自甲藻 Prorocentrum hoffmannianum 的神经活性超碳链化合物

Prorocentroic 酸 (PA) 是从甲藻Prorocentrum hoffmannianum 中分离出来的。其 35 个不对称中心的相对构型是通过 NMR 数据分析确定的，包括异核耦合和量子力学计算。通过使用在微电极阵列上生长的鼠皮层神经元来测试 PA。长期暴露于亚毒性浓度会导致神经元信号的显着重组，主要是通过爆发活动的变化。观察到的效果可能是由于可塑性过程的激活。