Internal Alkyne-Directed Fluorination of Unactivated C(sp3)–H Bonds,Organic Letters

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Internal Alkyne-Directed Fluorination of Unactivated C(sp3)–H Bonds
Organic Letters ( IF 4.9 ) Pub Date : 2020-11-23 , DOI: 10.1021/acs.orglett.0c03730
Chenyun Shu ₁ , Jian Feng ₁ , Hanliang Zheng ₂ , Cungui Cheng ₁ , Zheliang Yuan ₁ , Zuxiao Zhang ₁ , Xiao-Song Xue ₂ , Gangguo Zhu ₁

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A silver-mediated internal alkyne-guided fluorination of unactivated C(sp³)–H bonds is described. The reaction provides a facile access to γ-fluorinated fluoroalkylated (Z)-alkenes from readily available alkynes in promising yields with excellent regioselectivity, stereoselectivity, and site selectivity.

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