A Y(III)-based Metal–Organic Framework as a Carrier in Chemodynamic Therapy,Inorganic Chemistry

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A Y(III)-based Metal–Organic Framework as a Carrier in Chemodynamic Therapy
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2020-11-24 , DOI: 10.1021/acs.inorgchem.0c02525
Xia-Juan Huang ₁ , Shi-Jiang Yu ₁ , Yan Wang ₁ , Xiao-Kang Jin ₁ , Bing Wang ₁ , Lin-Hui Gao ₁ , Hong-Liang Zhu ₁ , Wen-Xin Lin _{1,

2} , Jian-Jun Chen ₁

Affiliation

A biocompatible Y(III)-based metal–organic framework [Y₄(TATB)₂]·(DMF)_3.5·(H₂O) (ZJU-16, H₃TATB= 4,4′,4′′-(1,3,5-triazine-2,4,6-triyl) tribenzoic acid) was synthesized, and it was adopted to load Mn²⁺ for chemodynamic therapy. Meanwhile, ibuprofen sodium (IBUNa), an anti-inflammatory drug, was introduced to increase the amount of Mn²⁺ (about 5.66 wt %) due to the low loading capacity of Mn²⁺. Mn&IBUNa@ZJU-16 which was loaded by Mn²⁺ and IBUNa exhibited significant effects of chemodynamic therapy and excellent inhibition of the 4T1 tumor cell growth, implying its long-term prospects in chemodynamic therapy and its possibility in bimodal cancer therapy.

中文翻译：

基于AY（III）的金属有机框架作为化学动力疗法的载体

具有生物相容性的Y（III）基金属-有机骨架[Y ₄（TATB）₂ ]·（DMF）_3.5 ·（H ₂ O）（ZJU-16，H ₃ TATB = 4,4′，4′′-（合成了1,3,5-三嗪-2,4,6-三基三苯甲酸），并负载Mn ²⁺进行化学动力学治疗。同时，由于Mn ²⁺的低负载能力，引入了抗炎药布洛芬钠（IBUNa）以增加Mn ^2+的含量（约5.66 wt％）。由Mn ²⁺加载的Mn＆IBUNa @ ZJU-16 IBUNa和IBUNa表现出显着的化学动力学治疗效果，并且对4T1肿瘤细胞的生长具有出色的抑制作用，这暗示了其在化学动力学治疗中的长期前景以及在双峰癌症治疗中的可能性。

更新日期：2020-11-24

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