Lung adenocarcinoma (LUAD) is a major pathological type of lung cancer. Understanding the mechanism of LUAD at the molecular level is important for a clinical decision. In this study, we use bioinformatic analysis to explore the prognostic value of P4HA1 in lung adenocarcinoma (LUAD) and the relationship with prognosis and tumor-infiltrating immune cells (TIICs). The results showed that the expression of P4HA1 was significantly higher in tumor tissues than in normal tissues for LUAD patients. Upregulated P4HA1 was related to stage and T classification. Kaplan-Meier analysis indicated that upregulation of P4HA1 was significantly related to worse overall survival (OS). Univariate and multivariate Cox analysis indicated P4HA1 remained to be an independent prognostic factor. GSEA showed that several cancer-related and immune-related signaling pathways exhibited prominently differential enrichment in P4HA1-high expression phenotype. In addition, the expression of P4HA1 was significantly correlated with proportion of several TIICs, particularly B cells and CD4+ T cells. In conclusion, our study confirmed that P4HA1 is a promising biomarker of poor prognosis and relates to immune infiltrates in LUAD.

中文翻译：

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P4HA1的过表达与肺腺癌的不良生存和免疫浸润相关

肺腺癌（LUAD）是肺癌的主要病理类型。在分子水平上了解LUAD的机制对于临床决策很重要。在这项研究中，我们使用生物信息学分析来探讨P4HA1在肺腺癌（LUAD）中的预后价值以及与预后和肿瘤浸润免疫细胞（TIICs）的关系。结果表明，对于LUAD患者，P4HA1在肿瘤组织中的表达明显高于正常组织。P4HA1上调与阶段和T分类有关。Kaplan-Meier分析表明，P4HA1的上调与较差的总体生存率（OS）显着相关。单因素和多因素Cox分析表明P4HA1仍然是独立的预后因素。GSEA显示，一些与癌症相关和与免疫相关的信号通路在P4HA1高表达表型中表现出明显的差异富集。另外，P4HA1的表达与几种TIIC的比例显着相关，特别是B细胞和CD4 + T细胞。总之，我们的研究证实P4HA1是一种预后不良的有前途的生物标志物，与LUAD的免疫浸润有关。