Two-Pronged Strategy of Biomechanically Active and Biochemically Multifunctional Hydrogel Wound Dressing To Accelerate Wound Closure and Wound Healing,Chemistry of Materials

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Two-Pronged Strategy of Biomechanically Active and Biochemically Multifunctional Hydrogel Wound Dressing To Accelerate Wound Closure and Wound Healing
Chemistry of Materials ( IF 7.2 ) Pub Date : 2020-11-24 , DOI: 10.1021/acs.chemmater.0c02823
Meng Li ₁ , Yongping Liang ₁ , Jiahui He ₁ , Hualei Zhang ₁ , Baolin Guo _{1,

2}

Affiliation

A two-pronged strategy of biomechanically active and biochemically functional hydrogel wound dressing which can assist wound closure and have multiple functions to promote wound healing has been rarely reported. Herein, we designed a series of biomechanically active injectable self-healing hydrogels based on quaternized chitosan (QCS), polydopamine-coated reduction graphene oxide (rGO-PDA), and poly(N-isopropylacrylamide) (PNIPAm) as multifunctional wound dressings to promote wound closure and wound healing. These biomechanically active wound dressings have excellent thermoresponsive self-contraction and tissue adhesion properties. They adhere strongly to the skin and assist wound closure by actively contracting wounds through self-contraction. Moreover, these hydrogels exhibit biochemical multifunctions that are beneficial to wound healing, including good self-healing property, temperature-dependent drug release ability, anti-infection, antioxidation, and conductivity. The in vivo full-thickness skin defect model demonstrates that the hydrogel dressings significantly promoted wound closure with accelerated wound contraction and promoted the wound-healing process with higher granulation tissue thickness, collagen disposition, and enhanced vascularization. In summary, the biomechanically active injectable self-healing conductive adhesive hydrogels promoted wound healing by assisting wound closure and biochemical functions, opening a two-pronged strategy approach to wound management through combining biomechanical and biochemical functions together.

中文翻译：

生物力学活性和生物化学多功能水凝胶伤口敷料的两管齐下的策略，以加速伤口闭合和伤口愈合

很少有生物力学活性和生物化学功能的水凝胶伤口敷料的两管齐下的策略，它可以帮助伤口闭合并具有促进伤口愈合的多种功能。本文中，我们设计了一系列基于季铵化壳聚糖（QCS），聚多巴胺涂层的还原氧化石墨烯（rGO-PDA）和聚（N）的生物力学活性的可注射自愈水凝胶。-异丙基丙烯酰胺）（PNIPAm）作为多功能伤口敷料，可促进伤口闭合和伤口愈合。这些具有生物力学活性的伤口敷料具有出色的热响应性自收缩和组织粘附特性。它们牢固地粘附在皮肤上，并通过自我收缩主动收缩伤口，从而帮助伤口闭合。而且，这些水凝胶显示出有益于伤口愈合的生化多功能，包括良好的自愈性能，温度依赖性药物释放能力，抗感染，抗氧化和导电性。体内全层皮肤缺损模型表明，水凝胶敷料显着促进伤口闭合并加速伤口收缩，并以更高的肉芽组织厚度，胶原蛋白沉积，并增强血管生成。总之，具有生物力学活性的可自我修复的导电胶水凝胶通过辅助伤口闭合和生化功能促进了伤口愈合，通过将生物力学和生化功能结合在一起，为伤口处理开辟了两管齐下的策略方法。

更新日期：2020-12-08

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