Nanoscale Mass Spectrometry Multimodal Imaging via Tip-Enhanced Photothermal Desorption,ACS Nano

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Nanoscale Mass Spectrometry Multimodal Imaging via Tip-Enhanced Photothermal Desorption
ACS Nano ( IF 15.8 ) Pub Date : 2020-11-24 , DOI: 10.1021/acsnano.0c05019
Matthias Lorenz _{1,

2} , Ryan Wagner ₃ , Stephen Jesse ₁ , Jennifer M. Marsh ₄ , Marc Mamak ₄ , Roger Proksch ₃ , Olga S. Ovchinnikova ₁

Affiliation

Materials ranging from adhesives, pharmaceuticals, lubricants, and personal care products are traditionally studied using macroscopic characterization techniques. However, their functionality is in reality defined by details of chemical organization on often noncrystalline matter with characteristic length scales on the order of microns to nanometers. Additionally, these materials are traditionally difficult to analyze using standard vacuum-based approaches that provide nanoscale chemical characterization due to their volatile and beam-sensitive nature. Therefore, approaches that operate under ambient conditions need to be developed that allow probing of nanoscale chemical phenomena and correlated functionality. Here, we demonstrate a tool for probing and visualizing local chemical environments and correlating them to material structure and functionality using advanced multimodal chemical imaging on a combined atomic force microscopy (AFM) and mass spectrometry (MS) system using tip-enhanced photothermal desorption with atmospheric pressure chemical ionization (APCI). We demonstrate enhanced performance metrics of the technique for correlated imaging and point sampling and illustrate the applicability for the analysis of trace chemicals on a human hair, additives in adhesives on paper, and pharmaceuticals samples notoriously difficult to analyze in a vacuum environment. Overall, this approach of correlating local chemical environments to structure and functionality is key to advancing research in many fields ranging from biology, to medicine, to material science.

中文翻译：

通过尖端增强的光热脱附进行的纳米级质谱多峰成像

传统上，使用宏观表征技术研究包括粘合剂，药物，润滑剂和个人护理产品在内的材料。但是，它们的功能性实际上是由通常具有特征长度尺度在微米到纳米量级的非晶体物质上的化学结构细节定义的。此外，传统上，这些材料难以使用基于真空的标准方法进行分析，这些方法由于具有挥发性和对光束敏感的特性，因此可以提供纳米级的化学表征。因此，需要开发在环境条件下运行的方法，以允许探测纳米级化学现象和相关功能。这里，我们展示了一种工具，该工具可在尖端力增强的光热解吸与大气压化学物质结合使用的原子力显微镜（AFM）和质谱（MS）系统上，通过先进的多峰化学成像技术来探测和可视化局部化学环境，并将其与材料结构和功能相关联电离（APCI）。我们展示了相关成像和点采样技术的增强性能指标，并说明了在真空环境中难以分析的分析人发上的微量化学物质，纸上粘合剂中的添加剂和药品样品的适用性。总体而言，这种将本地化学环境与结构和功能相关联的方法是推进生物学，医学，

更新日期：2020-12-22

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